دورية أكاديمية
Increased Escherichia coli-induced interleukin-23 production by CD16+ monocytes correlates with systemic immune activation in untreated HIV-1-infected individuals.
| العنوان: | Increased Escherichia coli-induced interleukin-23 production by CD16+ monocytes correlates with systemic immune activation in untreated HIV-1-infected individuals. |
|---|---|
| المؤلفون: | Manuzak JA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Dillon SM, Lee EJ, Dong ZM, Hecht DK, Wilson CC |
| المصدر: | Journal of virology [J Virol] 2013 Dec; Vol. 87 (24), pp. 13252-62. Date of Electronic Publication: 2013 Sep 25. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
| مواضيع طبية MeSH: | Escherichia coli/*immunology , Escherichia coli Infections/*immunology , HIV Infections/*immunology , HIV-1/*immunology , Interleukin-23/*immunology , Monocytes/*immunology , Receptors, IgG/*immunology, Adult ; Aged ; Case-Control Studies ; Cells, Cultured ; Dendritic Cells/immunology ; Escherichia coli/physiology ; Escherichia coli Infections/etiology ; Escherichia coli Infections/microbiology ; Female ; GPI-Linked Proteins/immunology ; HIV Infections/complications ; HIV Infections/virology ; HIV-1/physiology ; Humans ; Interleukin-10 ; Male ; Middle Aged ; Toll-Like Receptor 4/immunology ; Young Adult |
| مستخلص: | The level of microbial translocation from the intestine is increased in HIV-1 infection. Proinflammatory cytokine production by peripheral antigen-presenting cells in response to translocated microbes or microbial products may contribute to systemic immune activation, a hallmark of HIV-1 infection. We investigated the cytokine responses of peripheral blood myeloid dendritic cells (mDCs) and monocytes to in vitro stimulation with commensal enteric Escherichia coli in peripheral blood mononuclear cells (PBMC) from untreated HIV-1-infected subjects and from uninfected controls. Levels of interleukin 23 (IL-23) produced by PBMC from HIV-1-infected subjects in response to E. coli stimulation were significantly higher than those produced by PBMC from uninfected subjects. IL-23 was produced primarily by CD16(+) monocytes. This subset of monocytes was increased in frequency and expressed higher levels of Toll-like receptor 4 (TLR4) in HIV-1-infected individuals than in controls. Blocking TLR4 on total CD14(+) monocytes reduced IL-23 production in response to E. coli stimulation. Levels of soluble CD27, an indicator of systemic immune activation, were elevated in HIV-1-infected subjects and were associated with the percentage of CD16(+) monocytes and the induction of IL-23 by E. coli, providing a link between these parameters and systemic inflammation. Taken together, these results suggest that IL-23 produced by CD16(+) monocytes in response to microbial stimulation may contribute to systemic immune activation in HIV-1-infected individuals. |
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| معلومات مُعتمدة: | R01 DK088663 United States DK NIDDK NIH HHS; TL1 RR025778 United States RR NCRR NIH HHS; T32-AI07405 United States AI NIAID NIH HHS; T32 AI007405 United States AI NIAID NIH HHS; TL1 TR001081 United States TR NCATS NIH HHS; K24 AI074343 United States AI NIAID NIH HHS; UL1 TR001082 United States TR NCATS NIH HHS |
| المشرفين على المادة: | 0 (FCGR3B protein, human) 0 (GPI-Linked Proteins) 0 (Interleukin-23) 0 (Receptors, IgG) 0 (TLR4 protein, human) 0 (Toll-Like Receptor 4) 130068-27-8 (Interleukin-10) |
| تواريخ الأحداث: | Date Created: 20130927 Date Completed: 20140205 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3838250 |
| DOI: | 10.1128/JVI.01767-13 |
| PMID: | 24067979 |
| قاعدة البيانات: | MEDLINE |
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