دورية أكاديمية
أعرض في EDS

Buffalo alpha S1-casein gene 5'-flanking region and its interspecies comparison.

التفاصيل البيبلوغرافية
العنوان: Buffalo alpha S1-casein gene 5'-flanking region and its interspecies comparison.
المؤلفون: Patel AK; Department of Animal Biotechnology, College of Veterinary Science and Animal Husbandry, Anand Agricultural University, Anand, India., Singh M, Suryanarayana VV
المصدر: Journal of applied genetics [J Appl Genet] 2014 Feb; Vol. 55 (1), pp. 75-87. Date of Electronic Publication: 2013 Oct 19.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: England NLM ID: 9514582 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3883 (Electronic) Linking ISSN: 12341983 NLM ISO Abbreviation: J Appl Genet Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : Cheshire, United Kingdom : Springer
Original Publication: Poznań, Poland : Institute of Plant Genetics, Polish Academy of Sciences, 1995-
مواضيع طبية MeSH: 5' Flanking Region/*genetics , Buffaloes/*genetics , Caseins/*genetics, Animals ; Base Sequence ; Binding Sites ; Molecular Sequence Data ; Mutagenesis, Insertional ; Nucleotide Motifs ; Organ Specificity ; Promoter Regions, Genetic/genetics ; Repetitive Sequences, Nucleic Acid/genetics ; Retroelements ; Sequence Alignment ; Sequence Analysis, DNA
مستخلص: The expression of milk protein genes is tightly regulated in a spatio-temporal manner through the combinatorial interaction of lactogenic hormones and a set of transcription factors mediating developmental and tissue-specific gene expression. The recruitment of a unique set of transcription factors is determined by the cis-regulatory motifs present in the gene promoter region. Here, we report the isolation, sequencing, structural analysis and interspecies comparison of the 5'cis-regulatory region of the buffalo alpha S1 (αS1)-casein gene. The proximal promoter region of the buffalo αS1-casein gene harbored the insertion of a 72-bp fragment of long interspersed nuclear element of the L1_BT retrotransposon family. Among the core and vertebrate-specific promoter elements, the motifs for the binding of Brn POU domain factors (BRNF), Lim homeodomain factors (LHXF), NK6 homeobox transcription factors (NKX6), nuclear factor kappa B/c-rel (NFKB), AT-rich interactive domain factor (ARID), Brn POU domain factor 5 (BRN5), pancreatic and intestinal homeodomain transcription factor (PDX1), Distal-less homeodomain transcription factors (DLXF), T-cell factor/lymphoid enhancer-binding factor-1 (LEFF) and GHF-1 pituitary-specific POU domain transcription factor (PIT1) were over-represented in the αS1-casein gene regulatory region (Z score >4.0). The Multiple EM for Motif elicitation predicted three motifs which consisted of the sequences known to bind mammary gland factor/signal transducer and activator of transcription 5 (MGF/STAT5), estrogen receptor-related alpha (ERα), steroidogenic factor 1 (SF1) and glucocorticoid receptor (GR), indicating their potential role in the mammary gland-specific gene expression. The interspecies comparison of the proximal promoter region revealed conserved sequences for TATA boxes and MGF/STAT5 in all species, whereas activator protein 1 (AP1), pregnancy-specific mammary nuclear factor (PMF), CCAAT/enhancer binding protein (C/EBP), double-stranded and single-stranded DNA-binding protein 1 (DS1 and SS), ying and yang factor 1 (YY1), and GR half-sites were among ruminants. The functional significance of the L1_BT retrotransposon insertion on the buffalo αS1-casein gene expression needs to be experimentally validated.
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سلسلة جزيئية: GENBANK AF529305
المشرفين على المادة: 0 (Caseins)
0 (Retroelements)
تواريخ الأحداث: Date Created: 20131022 Date Completed: 20150417 Latest Revision: 20211021
رمز التحديث: 20231215
DOI: 10.1007/s13353-013-0176-7
PMID: 24142689
قاعدة البيانات: MEDLINE
الوصف
تدمد:2190-3883
DOI:10.1007/s13353-013-0176-7