دورية أكاديمية
أعرض في EDS

Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins.

التفاصيل البيبلوغرافية
العنوان: Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins.
المؤلفون: Dobrowsky TM; 1] Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA [2]., Rabi SA, Nedellec R, Daniels BR, Mullins JI, Mosier DE, Siliciano RF, Wirtz D
المصدر: Scientific reports [Sci Rep] 2013 Oct 22; Vol. 3, pp. 3014. Date of Electronic Publication: 2013 Oct 22.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Virus Attachment* , Virus Internalization*, HIV-1/*physiology , env Gene Products, Human Immunodeficiency Virus/*metabolism, CD4 Antigens/metabolism ; Cell Line ; Humans ; Protein Binding ; Protein Interaction Domains and Motifs ; Receptors, CCR5/metabolism ; Receptors, CXCR4/metabolism ; Receptors, HIV/metabolism ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/genetics
مستخلص: In about half of patients infected with HIV-1 subtype B, viral populations shift from utilizing the transmembrane protein CCR5 to CXCR4, as well as or instead of CCR5, during late stage progression of the disease. How the relative adhesion efficiency and fusion competency of the viral Env proteins relate to infection during this transition is not well understood. Using a virus-cell fusion assay and live-cell single-molecule force spectroscopy, we compare the entry competency of viral clones to tensile strengths of the individual Env-receptor bonds of Env proteins obtained from a HIV-1 infected patient prior to and during coreceptor switching. The results suggest that the genetic determinants of viral entry were predominantly enriched in the C3, HR1 and CD regions rather than V3. Env proteins can better mediate entry into cells after coreceptor switch; this effective entry capacity does not correlate with the bond strengths between viral Env and cellular receptors.
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معلومات مُعتمدة: GM084204 United States GM NIGMS NIH HHS; U54 CA143868 United States CA NCI NIH HHS; R01 AI047734 United States AI NIAID NIH HHS; United States HHMI Howard Hughes Medical Institute; CA143868 United States CA NCI NIH HHS; AI52778 United States AI NIAID NIH HHS; R01 GM084204 United States GM NIGMS NIH HHS; AI47734 United States AI NIAID NIH HHS; R01 CA085839 United States CA NCI NIH HHS; R37 AI047734 United States AI NIAID NIH HHS; R01 AI052778 United States AI NIAID NIH HHS; R56 AI052778 United States AI NIAID NIH HHS; P01 AI057005 United States AI NIAID NIH HHS; T32 AI007247 United States AI NIAID NIH HHS; CA85839 United States CA NCI NIH HHS; P30 AI027757 United States AI NIAID NIH HHS; AI 27757 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (CD4 Antigens)
0 (Receptors, CCR5)
0 (Receptors, CXCR4)
0 (Receptors, HIV)
0 (env Gene Products, Human Immunodeficiency Virus)
تواريخ الأحداث: Date Created: 20131023 Date Completed: 20140706 Latest Revision: 20230308
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3804852
DOI: 10.1038/srep03014
PMID: 24145278
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep03014