دورية أكاديمية
Effects of high and low 17β-estradiol doses on focal cerebral ischemia: negative results.
| العنوان: | Effects of high and low 17β-estradiol doses on focal cerebral ischemia: negative results. |
|---|---|
| المؤلفون: | Strom JO; Clinical Chemistry, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Department of Clinical Chemistry, County Council of Östergötland, Linköping, Sweden., Ingberg E, Theodorsson E, Theodorsson A |
| المصدر: | Scientific reports [Sci Rep] 2013 Nov 01; Vol. 3, pp. 3111. Date of Electronic Publication: 2013 Nov 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Brain Ischemia/*drug therapy , Brain Ischemia/*pathology , Estradiol/*administration & dosage, Animals ; Body Weight ; Brain Ischemia/mortality ; Brain Ischemia/physiopathology ; Cerebral Infarction/drug therapy ; Cerebral Infarction/mortality ; Cerebral Infarction/pathology ; Cerebral Infarction/physiopathology ; Disease Models, Animal ; Estradiol/pharmacokinetics ; Female ; Rats ; Time Factors |
| مستخلص: | The reasons why some animal studies indicate that estrogens increase focal cerebral ischemic damage while others show estrogen-induced neuroprotection has hitherto not been fully elucidated. Recent evidence indicates that discrepancies in hormone administration paradigms, resulting in highly different serum hormone concentrations, may account for the dichotomy. The current study aimed to test this hypothesis. Sixty ovariectomized female rats were randomized into three groups differing in 17β-estradiol regimens, and transient focal cerebral ischemia was subsequently induced. All animals were subjected to a small functional testing battery, and three days after MCAo they were sacrificed for infarct size assessment. Infarct sizes did not differ between groups, however clear discrepancies were seen in body weight and feeding behavior. In comparison to sham-operated animals, ovariectomized rats rapidly increased in body weight, whereas the opposite was seen in rats receiving 17beta-estradiol. The weight gain in the ovariectomized rats was paralleled by an increased food intake. |
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| المشرفين على المادة: | 4TI98Z838E (Estradiol) |
| تواريخ الأحداث: | Date Created: 20131102 Date Completed: 20151016 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6505964 |
| DOI: | 10.1038/srep03111 |
| PMID: | 24177749 |
| قاعدة البيانات: | MEDLINE |
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