دورية أكاديمية
Primary ovarian insufficiency in children after treatment with 131I-metaiodobenzylguanidine for neuroblastoma: report of the first two cases.
| العنوان: | Primary ovarian insufficiency in children after treatment with 131I-metaiodobenzylguanidine for neuroblastoma: report of the first two cases. |
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| المؤلفون: | Clement SC; Departments of Pediatric Endocrinology (S.C.C., H.M.v.S.) and Pediatric Oncology (K.C.J.M.K., C.v.d.B., L.C.M.K., G.A.M.T.), Emma Children's Hospital, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands; Department of Nuclear Medicine (B.L.F.v.E.-S.), Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands; and Department of Pediatric Endocrinology (H.M.v.S.), Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands., Kraal KC, van Eck-Smit BL, van den Bos C, Kremer LC, Tytgat GA, van Santen HM |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2014 Jan; Vol. 99 (1), pp. E112-6. Date of Electronic Publication: 2013 Dec 04. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مواضيع طبية MeSH: | 3-Iodobenzylguanidine/*adverse effects , Antineoplastic Agents/*adverse effects , Iodine Radioisotopes/*adverse effects , Neuroblastoma/*radiotherapy , Primary Ovarian Insufficiency/*etiology , Radiation Injuries/*etiology , Spinal Neoplasms/*radiotherapy, 3-Iodobenzylguanidine/therapeutic use ; Antineoplastic Agents/therapeutic use ; Child ; Female ; Humans ; Iodine Radioisotopes/therapeutic use ; Neuroblastoma/surgery ; Primary Ovarian Insufficiency/diagnosis ; Radiation Injuries/diagnosis ; Spinal Cord Compression/radiotherapy ; Spinal Cord Compression/surgery ; Spinal Neoplasms/surgery |
| مستخلص: | Background: Primary ovarian insufficiency (POI) is a noted late effect in childhood cancer survivors treated with alkylating agents or after radiation to a field that includes the ovaries. Gonadal failure in children with neuroblastoma (NBL) who were exposed to 131I- metaiodobenzylguanidine (MIBG) has only been reported in those who were also treated with chemotherapy. In these cases, the cause of gonadal failure was assumed to be the cytotoxic therapy. Here, we present the first two cases of POI after 131I-MIBG treatment only for NBL, indicating that 131I-MIBG treatment may have a causative role. Patients: During follow-up after treatment for NBL in childhood, elevated gonadotropins were found in a 12-year-old girl and an 11-year-old girl (FSH values, 105 and 161 U/L, respectively), indicating POI. The first patient had been diagnosed at the age of 17 months with sacrally located (intraspinal) NBL. Treatment consisted of five courses of 131I-MIBG and local resection. The second patient had been diagnosed at the age of 8 months with an abdominal (intraspinal) NBL. She had been treated with acute (neuro) surgery for decompression of her intraspinal tumor causing neurological symptoms, followed by two courses of 131I-MIBG therapy. Both girls had normal karyotypes (46, XX). No other cause for the ovarian failure was found. Estrogen suppletion was started, and patients and parents were counseled regarding fertility options. Conclusion: These two cases suggest that exposure to 131I-MIBG may damage the female gonads. Clinicians caring for childhood cancer survivors should be aware of the risk of POI after 131I-MIBG treatment. Prospective studies are warranted to confirm our observations. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Iodine Radioisotopes) 35MRW7B4AD (3-Iodobenzylguanidine) |
| تواريخ الأحداث: | Date Created: 20131105 Date Completed: 20140312 Latest Revision: 20140103 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1210/jc.2013-3595 |
| PMID: | 24187404 |
| قاعدة البيانات: | MEDLINE |
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