دورية أكاديمية
أعرض في EDS

Associations between adenotonsillar hypertrophy, age, and obesity in children with obstructive sleep apnea.

التفاصيل البيبلوغرافية
العنوان: Associations between adenotonsillar hypertrophy, age, and obesity in children with obstructive sleep apnea.
المؤلفون: Kang KT; Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan, R.O.C. ; Department of Otolaryngology, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan, R.O.C. ; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taiwan, R.O.C., Chou CH, Weng WC, Lee PL, Hsu WC
المصدر: PloS one [PLoS One] 2013 Oct 25; Vol. 8 (10), pp. e78666. Date of Electronic Publication: 2013 Oct 25 (Print Publication: 2013).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Obesity/*complications , Palatine Tonsil/*pathology , Sleep Apnea, Obstructive/*complications, Adiposity ; Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Hypertrophy/complications ; Infant ; Male ; Multivariate Analysis ; Organ Size
مستخلص: Objective: To investigate the contributions of adenoid and tonsil size to childhood obstructive sleep apnea (OSA) and the interactions between adenotonsillar hypertrophy, age, and obesity in children with OSA.
Methods: In total, 495 symptomatic patients were recruited. The patients were assigned to four groups according to age: toddler (age 1-3, n=42), preschool (age 3-6, n=164), school (age 6-12, n=200), and adolescence (age 12-18, n=89). All subjects had tonsil size graded by otolaryngologists, adenoid size determined on lateral radiographs (Fujioka method), and a full-night polysomnography. The apnea-hypopnea index (AHI), adenoid size, and tonsil size were compared in obese and non-obese children in the four age groups. Adjusted odds ratios (ORs) and 95% confidence interval (CI) of adenotonsillar hypertrophy and OSA risk were estimated by multi-logistic regression.
Results: The AHI was positively related to tonsil grade (r=0.33, p <0.001) and adenoid size (r=0.24, p <0.01) in all patients. Tonsil grade was positively related to AHI in all four age groups. Adenoid size was positively related to AHI in the toddler, preschool, school groups, but not in the adolescent group (r=0.11, p=0.37). Tonsil grade and adenoid size were both positively related to AHI in obese and non-obese children. In the regression model, obesity (OR=2.89; 95% CI 1.47-5.68), tonsillar hypertrophy (OR=3.15; 95% CI 2.04-4.88), and adenoidal hypertrophy (OR=1.89; 95% CI 1.19-3.00) significantly increased OSA risk.
Conclusions: Adenotonsillar hypertrophy and obesity are the major determinants of OSA in children. However, the influence of adenoid size decreases in adolescence.
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تواريخ الأحداث: Date Created: 20131109 Date Completed: 20140807 Latest Revision: 20220331
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3808373
DOI: 10.1371/journal.pone.0078666
PMID: 24205291
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0078666