دورية أكاديمية
Long term rectal function after high-dose prostatecancer radiotherapy: results from a prospective cohort study.
| العنوان: | Long term rectal function after high-dose prostatecancer radiotherapy: results from a prospective cohort study. |
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| المؤلفون: | Fellin G; Department of Radiotherapy, Ospedale Santa Chiara, Trento, Italy., Rancati T; Prostate Cancer Program, Ospedale San Raffaele, Milan, Italy. Electronic address: tiziana.rancati@istitutotumori.mi.it., Fiorino C; Department of Medical Physics, Milan, Italy., Vavassori V; Department of Radiotherapy, Ospedale di Circolo, Varese, Italy., Antognoni P; Department of Radiotherapy, Ospedale di Circolo, Varese, Italy., Baccolini M; Department of Medical Physics, Ospedale Villa Maria Cecilia, Lugo di Romagna, Italy., Bianchi C; Department of Medical Physics, Ospedale di Circolo, Varese, Italy., Cagna E; Department of Radiotherapy, Ospedale Sant'Anna, Como, Italy., Borca VC; Department of Medical Physics, Ospedale ASL 9, Ivrea, Italy., Girelli G; Department of Radiotherapy, Ospedale ASL 9, Ivrea, Italy., Iacopino B; Department of Radiotherapy, Policlinico Sant'Orsola Malpighi, Bologna, Italy., Maliverni G; Department of Radiotherapy, IRCC Candiolo, Italy., Mauro FA; Department of Radiotherapy, Ospedale Villa Maria Cecilia, Lugo di Romagna, Italy., Menegotti L; Department of Medical Physics, Ospedale Santa Chiara, Trento, Italy., Monti AF; Department of Medical Physics, Ospedale Sant'Anna, Como, Italy., Romani F; Department of Medical Physics, Policlinico Sant'Orsola Malpighi Bologna, Italy., Stasi M; Department of Medical Physics, IRCC Candiolo, Italy., Valdagni R; Prostate Cancer Program, Ospedale San Raffaele, Milan, Italy; Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. |
| المصدر: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2014 Feb; Vol. 110 (2), pp. 272-7. Date of Electronic Publication: 2013 Dec 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Original Publication: Amsterdam : Elsevier Science Publishers, c1983- |
| مواضيع طبية MeSH: | Prostatic Neoplasms/*physiopathology , Prostatic Neoplasms/*radiotherapy , Radiation Injuries/*etiology , Radiation Injuries/*physiopathology , Rectum/*physiopathology , Rectum/*radiation effects, Cohort Studies ; Fecal Incontinence/etiology ; Fecal Incontinence/physiopathology ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/physiopathology ; Humans ; Male ; Multivariate Analysis ; Nomograms ; Prospective Studies ; Radiotherapy Dosage ; Radiotherapy, Conformal/adverse effects |
| مستخلص: | Purpose: To prospectively evaluate long-term late rectal bleeding (lrb) and faecal incontinence (linc) after high-dose radiotherapy (RT) for prostate cancer in the AIROPROS 0102 population, and to assess clinical/dosimetric risk factors. Materials and Methods: Questionnaires of 515 patients with G0 baseline incontinence and bleeding scores (follow-up ≥6 years) were analysed. Correlations between lrb/linc and many clinical and dosimetric parameters were investigated by univariate and multivariate logistic analyses. The correlation between lrb/linc and symptoms during the first 3 years after RT was also investigated. Results: Of 515 patients lrb G1, G2 and G3 was found in 32 (6.1%), 2 (0.4%) and 3 (0.6%) patients while linc G1, G2 and G3 was detected in 50 (9.7%), 3 (0.6%) and 3 (0.6%), respectively. The prevalence of G2-G3 lrb events was significantly reduced compared to the first 3-years (1% vs 2.7%, p=0.016) ≥G1 lrb was significantly associated with V75 Gy (OR=1.07). In multivariate analysis, ≥G1 linc was associated with V40 Gy (OR=1.015), use of antihypertensive medication (OR=0.38), abdominal surgery before RT (OR=4.7), haemorrhoids (OR=2.6), and G2-G3 acute faecal incontinence (OR=4.4), a nomogram to predict the risk of long-term ≥G1 linc was proposed. Importantly, the prevalence of ≥G1 linc was significantly correlated with the mean incontinence score during the first 3 years after RT (OR=16.3). Conclusions: Long-term (median: 7 years) rectal symptoms are prevalently mild and strongly correlated with moderate/severe events occurring in the first 3 years after RT. Linc was associated with several risk factors. (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Dose–volume effects; Late toxicity; Normal tissue complication probability modeling; Prostate cancer; Radiotherapy |
| تواريخ الأحداث: | Date Created: 20131217 Date Completed: 20150126 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.radonc.2013.09.028 |
| PMID: | 24332020 |
| قاعدة البيانات: | MEDLINE |
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