دورية أكاديمية
أعرض في EDS

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation.

التفاصيل البيبلوغرافية
العنوان: Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation.
المؤلفون: Parisi C; 1] Cellular Biology and Neurobiology Institute, CNR, Via del Fosso di Fiorano 64, 00143 Rome, Italy [2] Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy., Arisi I; Genomics Facility, European Brain Research Institute EBRI 'Rita Levi-Montalcini', Via del Fosso di Fiorano 64, 00143 Rome, Italy., D'Ambrosi N; 1] Cellular Biology and Neurobiology Institute, CNR, Via del Fosso di Fiorano 64, 00143 Rome, Italy [2] Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy., Storti AE; Genomics Facility, European Brain Research Institute EBRI 'Rita Levi-Montalcini', Via del Fosso di Fiorano 64, 00143 Rome, Italy., Brandi R; Genomics Facility, European Brain Research Institute EBRI 'Rita Levi-Montalcini', Via del Fosso di Fiorano 64, 00143 Rome, Italy., D'Onofrio M; 1] Genomics Facility, European Brain Research Institute EBRI 'Rita Levi-Montalcini', Via del Fosso di Fiorano 64, 00143 Rome, Italy [2] Istituto di Farmacologia Traslazionale, CNR, Via del Fosso del Cavaliere 100, 00133 Rome, Italy., Volonté C; 1] Cellular Biology and Neurobiology Institute, CNR, Via del Fosso di Fiorano 64, 00143 Rome, Italy [2] Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy.
المصدر: Cell death & disease [Cell Death Dis] 2013 Dec 12; Vol. 4, pp. e959. Date of Electronic Publication: 2013 Dec 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Pub. Group
مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis/*genetics , MicroRNAs/*genetics , Microglia/*metabolism, Animals ; Cells, Cultured ; Interleukin-6/genetics ; Mice ; Microglia/drug effects ; Purinergic P2X Receptor Agonists/pharmacology ; Superoxide Dismutase/genetics ; Superoxide Dismutase-1 ; Tumor Necrosis Factor-alpha/genetics
مستخلص: MicroRNAs (miRNAs) regulate gene expression at post-transcriptional level and are key modulators of immune system, whose dysfunction contributes to the progression of neuroinflammatory diseaseas such as amyotrophic lateral sclerosis (ALS), the most widespread motor neuron disorder. ALS is a non-cell-autonomous disease targeting motor neurons and neighboring glia, with microgliosis directly contributing to neurodegeneration. As limited information exists on miRNAs dysregulations in ALS, we examined this topic in primary microglia from superoxide dismutase 1-G93A mouse model. We compared miRNAs transcriptional profiling of non-transgenic and ALS microglia in resting conditions and after inflammatory activation by P2X7 receptor agonist. We identified upregulation of selected immune-enriched miRNAs, recognizing miR-22, miR-155, miR-125b and miR-146b among the most highly modulated. We proved that miR-365 and miR-125b interfere, respectively, with the interleukin-6 and STAT3 pathway determining increased tumor necrosis factor alpha (TNFα) transcription. As TNFα directly upregulated miR-125b, and inhibitors of miR-365/miR-125b reduced TNFα transcription, we recognized the induction of miR-365 and miR-125b as a vicious gateway culminating in abnormal TNFα release. These results strengthen the impact of miRNAs in modulating inflammatory genes linked to ALS and identify specific miRNAs as pathogenetic mechanisms in the disease.
References: J Immunol. 2013 May 15;190(10):5187-95. (PMID: 23589615)
Glia. 2011 Jan;59(1):1-13. (PMID: 20878769)
Science. 2009 Dec 11;326(5959):1549-54. (PMID: 20007902)
Nat Med. 2011 Jan;17(1):64-70. (PMID: 21131957)
Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):31-8. (PMID: 22093834)
J Neurochem. 2002 Jan;80(1):158-67. (PMID: 11796754)
Prog Neurobiol. 2011 Oct;95(2):229-74. (PMID: 21907261)
Acta Neuropathol. 2010 Sep;120(3):277-86. (PMID: 20644946)
J Inorg Biochem. 2007 Sep;101(9):1265-9. (PMID: 17629564)
J Exp Med. 2011 Nov 21;208(12):2429-47. (PMID: 22084410)
Nat Rev Immunol. 2011 Oct 25;11(11):775-87. (PMID: 22025055)
RNA. 2010 May;16(5):991-1006. (PMID: 20360395)
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13111-6. (PMID: 20616011)
Blood. 2011 Apr 21;117(16):4338-48. (PMID: 21368288)
J Immunol. 2010 Jan 1;184(1):21-5. (PMID: 19949084)
Cell Signal. 2010 Jul;22(7):977-83. (PMID: 20096353)
Curr Neurol Neurosci Rep. 2006 Jan;6(1):37-46. (PMID: 16469270)
Biochim Biophys Acta. 2011 May;1813(5):878-88. (PMID: 21296109)
J Comp Neurol. 2008 Jan 1;506(1):75-92. (PMID: 17990272)
BMC Neurol. 2006 Mar 02;6:12. (PMID: 16512913)
J Immunol. 1991 Apr 1;146(7):2316-23. (PMID: 2005401)
Mol Cell. 2012 Dec 14;48(5):760-70. (PMID: 23142080)
Trends Neurosci. 1997 Jun;20(6):252-8. (PMID: 9185306)
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5003-8. (PMID: 21383194)
Trends Neurosci. 2012 May;35(5):325-34. (PMID: 22436491)
Science. 1994 Jun 17;264(5166):1772-5. (PMID: 8209258)
J Neurol Neurosurg Psychiatry. 2010 Jul;81(7):764-7. (PMID: 20176600)
Glia. 2004 Nov 1;48(2):179-82. (PMID: 15378658)
Trends Cell Biol. 2013 Jan;23(1):30-6. (PMID: 23026030)
Hum Mol Genet. 2013 Oct 15;22(20):4102-16. (PMID: 23736299)
Exp Neurol. 2012 Sep;237(1):147-52. (PMID: 22735487)
J Immunol. 1989 Dec 1;143(11):3517-23. (PMID: 2584704)
J Mol Cell Biol. 2011 Jun;3(3):159-66. (PMID: 21502305)
Oncogene. 2006 Oct 9;25(46):6163-9. (PMID: 17028595)
Mol Neurobiol. 2012 Aug;46(1):11-9. (PMID: 22302353)
CNS Neurol Disord Drug Targets. 2012 Sep;11(6):705-21. (PMID: 22963440)
Transl Res. 2011 Apr;157(4):163-79. (PMID: 21420027)
J Immunol. 2011 Nov 15;187(10):5062-8. (PMID: 22003200)
Glia. 2008 Jun;56(8):888-94. (PMID: 18338796)
J Biol Chem. 2011 Nov 18;286(46):40151-62. (PMID: 21937428)
Immunity. 2010 May 28;32(5):593-604. (PMID: 20510870)
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7594-9. (PMID: 18492803)
J Immunol. 2009 Oct 1;183(7):4648-56. (PMID: 19734218)
Leukemia. 2012 Mar;26(3):404-13. (PMID: 22182919)
Neuromolecular Med. 2012 Dec;14(4):317-27. (PMID: 22772723)
Rev Neurosci. 2010;21(4):251-72. (PMID: 21086759)
J Biol Chem. 2011 Jun 17;286(24):21401-12. (PMID: 21518763)
Nat Neurosci. 2007 Nov;10(11):1355-60. (PMID: 17965655)
Cell. 2007 Jun 29;129(7):1401-14. (PMID: 17604727)
Neuron. 2006 Oct 5;52(1):39-59. (PMID: 17015226)
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):16021-6. (PMID: 17043238)
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17913-8. (PMID: 18997009)
J Neurochem. 2004 Oct;91(1):133-43. (PMID: 15379894)
Nat Neurosci. 2007 May;10(5):615-22. (PMID: 17435755)
Lancet. 2011 Mar 12;377(9769):942-55. (PMID: 21296405)
Glia. 2008 Jan 15;56(2):190-9. (PMID: 18023015)
Nucleic Acids Res. 2010 Nov;38(20):7248-59. (PMID: 20615901)
J Immunol. 2007 Oct 15;179(8):5082-9. (PMID: 17911593)
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W451-4. (PMID: 16845047)
J Clin Invest. 2012 Sep;122(9):3063-87. (PMID: 22863620)
المشرفين على المادة: 0 (Interleukin-6)
0 (MicroRNAs)
0 (Mirn125 microRNA, mouse)
0 (Mirn146 microRNA, mouse)
0 (Mirn155 microRNA, mouse)
0 (Mirn22 microRNA, mouse)
0 (Purinergic P2X Receptor Agonists)
0 (Tumor Necrosis Factor-alpha)
EC 1.15.1.1 (Sod1 protein, mouse)
EC 1.15.1.1 (Superoxide Dismutase)
EC 1.15.1.1 (Superoxide Dismutase-1)
تواريخ الأحداث: Date Created: 20131217 Date Completed: 20140612 Latest Revision: 20220309
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3877562
DOI: 10.1038/cddis.2013.491
PMID: 24336079
قاعدة البيانات: MEDLINE
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا