دورية أكاديمية
Antidepressants and gastrointestinal symptoms in the general Dutch adult population.
| العنوان: | Antidepressants and gastrointestinal symptoms in the general Dutch adult population. |
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| المؤلفون: | Schurink B; From the *Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen; †Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht; ‡Department of Cardiology, Radboud University Medical Center, Nijmegen; §Department of Gastroenterology and Hepatology, Elkerliek Hospital, Helmond; and ∥Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands; and ¶Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA., Tielemans MM, Aaldering BR, Eikendal T, Focks JJ, Laheij RJ, Jansen JB, van Rossum LG, van Oijen MG |
| المصدر: | Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2014 Feb; Vol. 34 (1), pp. 66-71. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Williams And Wilkins Country of Publication: United States NLM ID: 8109496 Publication Model: Print Cited Medium: Internet ISSN: 1533-712X (Electronic) Linking ISSN: 02710749 NLM ISO Abbreviation: J Clin Psychopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Baltimore Md : Williams And Wilkins Original Publication: Baltimore, Md. : Williams & Wilkins, [c1981- |
| مواضيع طبية MeSH: | Antidepressive Agents/*therapeutic use , Gastrointestinal Diseases/*epidemiology, Adult ; Aged ; Antidepressive Agents/adverse effects ; Chi-Square Distribution ; Comorbidity ; Cross-Sectional Studies ; Female ; Gastrointestinal Diseases/chemically induced ; Gastrointestinal Diseases/diagnosis ; Health Surveys ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Netherlands/epidemiology ; Odds Ratio ; Risk Assessment ; Risk Factors ; Surveys and Questionnaires |
| مستخلص: | Background: Gastrointestinal symptoms are frequently reported adverse effects of antidepressants, but antidepressants are also a treatment modality in functional gastrointestinal disorders. We aimed to assess the association between antidepressant use and gastrointestinal symptoms in the general adult population. Methods: We assessed gastrointestinal symptoms, medication use, and comorbidity through structured questionnaires in randomly selected individuals. We compared presence of gastrointestinal symptoms in respondents who reported antidepressant use with those who did not. We used multivariable regression analysis to verify the association between antidepressant use and gastrointestinal symptoms. Results: In total, 16,758 questionnaires were returned and eligible for analysis. Antidepressant use was reported by 701 respondents (4.2%). Gastrointestinal symptoms were more frequently reported by antidepressant users compared with nonusers (40% vs 25%, P < 0.01). This apparent association between antidepressant use and gastrointestinal symptoms did not remain after adjusting for demographic factors, comorbidity, and use of other medications (adjusted odds ratio, 0.94; 95% confidence interval, 0.74-1.18). Conclusions: In our cross-sectional population-based study, we did not find an association between antidepressant use and gastrointestinal symptoms. |
| المشرفين على المادة: | 0 (Antidepressive Agents) |
| تواريخ الأحداث: | Date Created: 20131219 Date Completed: 20140829 Latest Revision: 20151119 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/JCP.0000000000000055 |
| PMID: | 24346754 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1533-712X |
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| DOI: | 10.1097/JCP.0000000000000055 |