دورية أكاديمية
[Long-term outcomes of childhood lymphoblastic lymphoma: report of 70 cases].
| العنوان: | [Long-term outcomes of childhood lymphoblastic lymphoma: report of 70 cases]. |
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| المؤلفون: | Xu Z; Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China., Pan C, Chen J, Xue HL, Ye QD, Zhou M, Luo CY, Jiang H, Li BS, Tang YJ, Wang JM, Dong L, Tang JY |
| المصدر: | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2013 Dec; Vol. 34 (12), pp. 1044-9. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Chinese Medical Association Country of Publication: China NLM ID: 8212398 Publication Model: Print Cited Medium: Print ISSN: 0253-2727 (Print) Linking ISSN: 02532727 NLM ISO Abbreviation: Zhonghua Xue Ye Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Chinese Medical Association Original Publication: Beijing : Zhongguo yi xue ke xue yuan. |
| مواضيع طبية MeSH: | Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy, Adolescent ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Prognosis ; Prospective Studies ; Treatment Outcome |
| مستخلص: | Objective: To summarize long-term outcomes of childhood lymphoblastic lymphoma (LBL) with protocol CCCG-97 and -2002. Methods: From November 1998 to October 2010, 70 consecutive newly diagnosed childhood LBL (5 B-LBL and 65 T-LBL) were enrolled in this study, in which 22 received CCCG-97 and 48 CCCG-2002 protocols. St.Jude staging system was adopted. Patients were divided into three risk groups based on clinical stage and serum LDH, and received chemotherapy with different intensity. The factors, which were possibly associated with the prognosis, were analyzed. The survival rates were evaluated by Kaplan-Meier analysis. Results: The patients were 1.5 to 14 years old with the median age of 8 years old. They were evaluated as stage I-II for 6 , stage III41, and stage IV23 (15 were BM positive and 8 multiple bone metastases). Until Dec.31th, 2011,the mean follow-up was 62.5 months (range, 14 to 161 months) with the median follow-up of 48 months. 1-year overall survival (OS) was 74.3%, and 5- year event-free survival (EFS) 64.1% (abundance as event). Thirteen patients were complicated with serious condition during chemotherapy and 1 died of complication. Univariate analysis indicated that delayed and/or non-completed response on days 33 and 63 of induction was the unfavorable prognostic factor. Conclusion: Primary LBL usually located in the mediastinum. 90% of the patients was at advanced stage III-IV at first presentation. The 5-year EFS was 64.1%. Patients not achieved CR at days 33 and 63 at the end of induction was a poor prognostic factor. |
| تواريخ الأحداث: | Date Created: 20131227 Date Completed: 20150219 Latest Revision: 20131226 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3760/cma.j.issn.0253-2727.2013.12.010 |
| PMID: | 24369162 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0253-2727 |
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| DOI: | 10.3760/cma.j.issn.0253-2727.2013.12.010 |