دورية أكاديمية
Autonomic dysfunction assessed by EZSCAN and subclinical atherosclerosis.
| العنوان: | Autonomic dysfunction assessed by EZSCAN and subclinical atherosclerosis. |
|---|---|
| المؤلفون: | Sun J; Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Laboratory of Endocrine and Metabolic Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Shanghai, China., Zhang Y, Xu B, Lv X, Ding L, Chen Y, Sun W, Lu J, Xu M, Bi Y, Ning G |
| المصدر: | Journal of diabetes [J Diabetes] 2014 Sep; Vol. 6 (5), pp. 409-16. Date of Electronic Publication: 2014 Mar 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Publishing Asia Country of Publication: Australia NLM ID: 101504326 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1753-0407 (Electronic) Linking ISSN: 17530407 NLM ISO Abbreviation: J Diabetes Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Richmond, Vic. : Blackwell Publishing Asia, 2009- |
| مواضيع طبية MeSH: | Atherosclerosis/*diagnosis , Autonomic Nervous System/*physiopathology , Autonomic Nervous System Diseases/*diagnosis , Sweat Glands/*innervation, Aged ; Ankle Brachial Index ; Asymptomatic Diseases ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/epidemiology ; Atherosclerosis/physiopathology ; Autonomic Nervous System Diseases/epidemiology ; Autonomic Nervous System Diseases/physiopathology ; Carotid Intima-Media Thickness ; China/epidemiology ; Chlorides/analysis ; Cross-Sectional Studies ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Predictive Value of Tests ; Prevalence ; Pulse Wave Analysis ; Risk Factors ; Sweat/chemistry |
| مستخلص: | Background: The present study aimed to explore the association between autonomic dysfunction and measurements of atherosclerosis in a middle-aged and elderly Chinese population. Methods: A population-based cross-sectional study was performed in Shanghai, China, from March to August 2010, with 5076 participants included in the analysis. Autonomic function was assessed by a novel EZSCAN test based on sudomotor function analysis. Carotid intima-media thickness (CIMT) was measured using B-mode ultrasonography and brachial-ankle pulse wave velocity (ba-PWV) was measured using an autonomic device. Participants were divided into three groups based on EZSCAN values: Group 1: EZSCAN 0-24; Group 2, EZSCAN 25-49; and Group 3, EZSCAN 50-100. These groups denoted autonomic dysfunction risk groups as follows: no risk, moderate risk and high risk, respectively. Results: The prevalence of elevated CIMT and ba-PWV increased markedly with increasing EZSCAN values (elevated CIMT 7.4%, 17.5%, and 29.7%, elevated ba-PWV 3.2%, 19.7%, and 36.5%, in Groups 1, 2, and 3, respectively; both Ptrend < 0.0001). Logistic regressions revealed that EZSCAN values ≥50 were associated with a non-significantly higher risk of elevated CIMT (odds ratio [OR] = 1.43; 95% confidence interval [CI] 0.98-2.07) and a significantly higher risk of elevated ba-PWV (OR = 2.16; 95% CI 1.25-3.71) compared with EZSCAN values <25, after controlling for conventional risk factors. Conclusion: A higher EZSCAN value (≥50), an index of high autonomic dysfunction risk, was associated with an increased risk of elevated ba-PWV and CIMT. Such associations were partially explained by traditional atherosclerotic risk factors. (© 2014 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.) |
| فهرسة مساهمة: | Keywords: EZSCAN test; atherosclerosis; autonomic dysfunction; brachial-ankle pulse wave velocity; carotid intima-media thickness; 关键词：动脉粥样硬化，自主神经紊乱，肱踝脉搏波传导速度，颈动脉内中膜厚度，EZSCAN 检测 |
| المشرفين على المادة: | 0 (Chlorides) |
| تواريخ الأحداث: | Date Created: 20140211 Date Completed: 20150511 Latest Revision: 20161125 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1111/1753-0407.12135 |
| PMID: | 24506497 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1753-0407 |
|---|---|
| DOI: | 10.1111/1753-0407.12135 |