دورية أكاديمية
[Research progress and prospect of universal influenza vaccine].
| العنوان: | [Research progress and prospect of universal influenza vaccine]. |
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| المؤلفون: | Luo DY; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China. don.gdon.g@163.com, Xue CY; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China., Cao YC; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China. |
| المصدر: | Bing du xue bao = Chinese journal of virology [Bing Du Xue Bao] 2013 Nov; Vol. 29 (6), pp. 646-50. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Chung-Kuo Wei Sheng Wu Hsueh Hui Country of Publication: China NLM ID: 8803009 Publication Model: Print Cited Medium: Print ISSN: 1000-8721 (Print) Linking ISSN: 10008721 NLM ISO Abbreviation: Bing Du Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Chung-Kuo Wei Sheng Wu Hsueh Hui Original Publication: [Peking] : Zhongguo wei sheng wu xue hui, 1985- |
| مواضيع طبية MeSH: | Influenza Vaccines/*immunology , Influenza, Human/*prevention & control , Orthomyxoviridae/*immunology, Animals ; Biomedical Research/trends ; Humans ; Influenza Vaccines/genetics ; Influenza, Human/immunology ; Influenza, Human/virology ; Orthomyxoviridae/genetics ; Viral Proteins/genetics ; Viral Proteins/immunology |
| مستخلص: | The constant outbreaks of influenza in a global scale have aroused great concern all over the world. Vaccine has been the most effective and economic means against influenza. However, the broad tropism and high mutation of influenza viruses have limited the effectiveness of influenza vaccines. Current influenza virus vaccines provide effective protection against virus strains that are identical or highly similar to the vaccine strain. Once a highly mutated or new strain of influenza virus appears, the current vaccine would lose its effectiveness. Therefore, the development of a universal vaccine against highly mutated or new influenza virus subtypes has become a hot spot in the field of influenza vaccine research. The major methods of developing the universal influenza vaccine are to select a conserved protein of influenza virus as an antigen. At least three universal influenza vaccines have been tested in clinical trials. Moreover, changing the routes of vaccine immunization and immunization schemes could also improve the effect of heterosubtypic immunity. This review summarized the research progresses of universal influenza vaccines and provided our prospective on universal influenza vaccine research. |
| المشرفين على المادة: | 0 (Influenza Vaccines) 0 (Viral Proteins) |
| تواريخ الأحداث: | Date Created: 20140214 Date Completed: 20140401 Latest Revision: 20161021 |
| رمز التحديث: | 20231215 |
| PMID: | 24520771 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1000-8721 |
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