دورية أكاديمية
Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women.
| العنوان: | Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women. |
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| المؤلفون: | Klop B; Department of Internal Medicine, Sint Franciscus Gasthius, Rotterdam, The Netherlands., van de Geijn GJ; Department of Clinical Chemistry, Sint Franciscus Gasthius, Rotterdam, The Netherlands., Birnie E; Department of Statistics and Education, Sint Franciscus Gasthius, Rotterdam, The Netherlands., Njo TL; Department of Clinical Chemistry, Sint Franciscus Gasthius, Rotterdam, The Netherlands., Janssen HW; Department of Clinical Chemistry, Sint Franciscus Gasthius, Rotterdam, The Netherlands., Jansen HG; Department of Clinical Pharmacy, Sint Franciscus Gasthuis, Rotterdam, The Netherlands., Jukema JW; 1] Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands [2] Interuniversity Cardiology Institute of The Netherlands (ICIN), Utrecht, The Netherlands., Elte JW; Department of Internal Medicine, Sint Franciscus Gasthius, Rotterdam, The Netherlands., Castro Cabezas M; Department of Internal Medicine, Sint Franciscus Gasthius, Rotterdam, The Netherlands. |
| المصدر: | European journal of clinical nutrition [Eur J Clin Nutr] 2014 May; Vol. 68 (5), pp. 635-7. Date of Electronic Publication: 2014 Mar 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5640 (Electronic) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: London : Nature Publishing Group Original Publication: London : J. Libbey, c1988- |
| مواضيع طبية MeSH: | Dietary Supplements*, Cholecalciferol/*administration & dosage , Leukocytes/*drug effects , Postprandial Period/*drug effects , Vascular Stiffness/*drug effects, Adolescent ; Adult ; Area Under Curve ; Biomarkers/blood ; CD11b Antigen/genetics ; CD11b Antigen/metabolism ; CD36 Antigens/genetics ; CD36 Antigens/metabolism ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Female ; Humans ; Inflammation/drug therapy ; Leukocytes/metabolism ; Male ; Middle Aged ; Receptors, Complement 3b/genetics ; Receptors, Complement 3b/metabolism ; Young Adult |
| مستخلص: | Postprandial inflammation is considered to be pro-atherogenic. Vitamin D can reduce inflammation and arterial stiffness. We hypothesized that vitamin D3 improves postprandial arterial elasticity by the modulation of leukocyte activation. Healthy volunteers underwent two oral fat-loading tests (OFLTs). The augmentation index (AIx) and flow cytometric quantification of leukocyte activation markers were measured. After the first OFLT, 100 000 IU of vitamin D3 was administered and a second OFLT was carried out 7 days later. Six men and six women were included. A favorable reduction in AIx was found after vitamin D3 supplementation (P=0.042) in both genders. After vitamin D3, exclusively in women a reduction in the area under the postprandial curve for monocytes CD11b and CD35 by 10.5% (P=0.016) and 12.5% (P=0.04) and neutrophil CD11b by 17.0% (P=0.014) was observed. In conclusion, vitamin D3 probably increased postprandial arterial elasticity in men and women, but reduced postprandial leukocyte activation exclusively in women. |
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| المشرفين على المادة: | 0 (Biomarkers) 0 (CD11b Antigen) 0 (CD36 Antigens) 0 (CR1 protein, human) 0 (ITGAM protein, human) 0 (Receptors, Complement 3b) 1C6V77QF41 (Cholecalciferol) |
| تواريخ الأحداث: | Date Created: 20140313 Date Completed: 20141223 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1038/ejcn.2014.29 |
| PMID: | 24619107 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1476-5640 |
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| DOI: | 10.1038/ejcn.2014.29 |