دورية أكاديمية
Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels.
| العنوان: | Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels. |
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| المؤلفون: | Wonnerth A; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria. Electronic address: anna.wonnerth@gmail.com., Katsaros KM; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research., Krychtiuk KA; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Speidl WS; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Kaun C; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research., Thaler K; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Huber K; Ludwig Boltzmann Cluster for Cardiovascular Research; Department of Cardiology and Emergency Medicine, Wilhelminenspital, Vienna, Austria., Wojta J; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research., Maurer G; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Seljeflot I; Centre of Clinical Heart Research, Oslo University Hospital, Ulleval, Norway; Faculty of Medicine, University of Oslo, Norway., Arnesen H; Centre of Clinical Heart Research, Oslo University Hospital, Ulleval, Norway., Weiss TW; Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria; Department of Cardiology and Emergency Medicine, Wilhelminenspital, Vienna, Austria. |
| المصدر: | Metabolism: clinical and experimental [Metabolism] 2014 May; Vol. 63 (5), pp. 647-53. Date of Electronic Publication: 2014 Feb 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : W.B. Saunders Original Publication: New York, Grune & Stratton. |
| مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Cytokine Receptor gp130/*blood , Glycoproteins/*genetics, Aged ; Amino Acid Substitution ; Cohort Studies ; Cysteine/genetics ; Gene Frequency ; Glycine/genetics ; Humans ; Inflammation/blood ; Inflammation/genetics ; Interleukin-6/blood ; Male ; Middle Aged ; Receptors, Interleukin-6/blood |
| مستخلص: | Objective: Interleukin-6 (IL-6) is a key cytokine in inflammatory diseases. It exerts its biological function via binding to a homodimer of its signal transducer glycoprotein 130 (gp130). Soluble gp130 (sgp130) is the natural inhibitor of IL-6 trans-signalling. The aim of this study was to test a possible influence of the gp130 genotype on sgp130 serum levels. Material and Methods: In two separate populations, subjects were genotyped for the gp130 polymorphism G148C. Sgp130, IL-6 and soluble interleukin-6 receptor (sIL-6R) levels were measured. The OSLO population consisted of 546 male subjects at high risk for CAD. The VIENNA population consisted of 299 male subjects with angiographically proven CAD. Results: In the OSLO population, 124 (22.7%) subjects were hetero- or homozygote for the rare C allele. Individuals carrying the polymorphism had significantly higher levels of sgp130. In a multivariate linear regression model this association remained significant (adjusted p=0.001). In the VIENNA population, 48 (16.1%) subjects were hetero- or homozygote for the rare C allele. Consistent with the former study, sgp130 levels were significantly higher in carriers of the polymorphism compared to wildtype carriers (adjusted p=0.038). In the VIENNA population, sgp130 levels were significantly higher in diabetic patients. In the OSLO population, sgp130 was higher in patients with increased body mass index and in smokers (p<0.05). Conclusions: Sgp130 serum levels are significantly higher in subjects carrying the gp130 polymorphism G148C compared to wildtype carriers. This finding proposes a possible genetical influence on sgp130 levels which may alter individual coping mechanisms in inflammatory diseases. (Copyright © 2014 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Coronary artery disease; Inflammation; Interleukin-6; Soluble interleukin-6 receptor |
| المشرفين على المادة: | 0 (Glycoproteins) 0 (Interleukin-6) 0 (Receptors, Interleukin-6) 0 (glycoprotein 130, human) 133483-10-0 (Cytokine Receptor gp130) K848JZ4886 (Cysteine) TE7660XO1C (Glycine) |
| تواريخ الأحداث: | Date Created: 20140318 Date Completed: 20140604 Latest Revision: 20140421 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.metabol.2014.02.005 |
| PMID: | 24629561 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-8600 |
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| DOI: | 10.1016/j.metabol.2014.02.005 |