دورية أكاديمية
أعرض في EDS

Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice.

التفاصيل البيبلوغرافية
العنوان: Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice.
المؤلفون: Kim JH; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Meyers MS; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Khuder SS; Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA., Abdallah SL; Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA., Muturi HT; Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA., Russo L; Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA., Tate CR; Department of Medicine, Division of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA., Hevener AL; Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Najjar SM; Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA., Leloup C; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Mauvais-Jarvis F; Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ; Department of Medicine, Division of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.
المصدر: Molecular metabolism [Mol Metab] 2014 Jan 09; Vol. 3 (2), pp. 177-90. Date of Electronic Publication: 2014 Jan 09 (Print Publication: 2014).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: eCollection Cited Medium: Print ISSN: 2212-8778 (Print) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [München] : Elsevier GmbH, 2012-
مستخلص: Pairing the selective estrogen receptor modulator bazedoxifene (BZA) with estrogen as a tissue-selective estrogen complex (TSEC) is a novel menopausal therapy. We investigated estrogen, BZA and TSEC effects in preventing diabetisity in ovariectomized mice during high-fat feeding. Estrogen, BZA or TSEC prevented fat accumulation in adipose tissue, liver and skeletal muscle, and improved insulin resistance and glucose intolerance without stimulating uterine growth. Estrogen, BZA and TSEC improved energy homeostasis by increasing lipid oxidation and energy expenditure, and promoted insulin action by enhancing insulin-stimulated glucose disposal and suppressing hepatic glucose production. While estrogen improved metabolic homeostasis, at least partially, by increasing hepatic production of FGF21, BZA increased hepatic expression of Sirtuin1, PPARα and AMPK activity. The metabolic benefits of BZA were lost in estrogen receptor-α deficient mice. Thus, BZA alone or in TSEC produces metabolic signals of fasting and caloric restriction and improves energy and glucose homeostasis in female mice.
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معلومات مُعتمدة: R01 DK083850 United States DK NIDDK NIH HHS; R01 HL112248 United States HL NHLBI NIH HHS; R01 DK074970 United States DK NIDDK NIH HHS; R01 DK054254 United States DK NIDDK NIH HHS; R01 DK089109 United States DK NIDDK NIH HHS; P30 DK020572 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: AMPKα, AMP-activated protein kinase α; AUC, area-under the curve; Akt, protein kinase B; BAT, brown adipose tissue; BZA, bazedoxifene; Bazedoxifene; CE, conjugated equine estrogens; E2, 17β-estradiol; ER, estrogen receptor; FAS, fatty acid synthase; FGF21, fibroblast growth factor 21; GIR, glucose infusion rate; H&E, hematoxylin and eosin; HFD, high-fat diet; HGP, hepatic glucose production; ITT, insulin tolerance test; Insulin resistance; LPL, lipoprotein lipase; Lcn2, lipocalin 2; Menopause; Metabolic syndrome; NAFLD, non-alcoholic fatty liver disease; OGTT, oral glucose tolerance test; OVX, ovariectomy; PTT, pyruvate tolerance test; RBP4, retinol binding protein 4; RER, respiratory exchange ratio; Rd, rate of whole-body glucose disappearance; SERM, selective estrogen receptor modulator; TBARS, thiobarbituric acid reactive substances; TG, triacylglycerol; TSEC, tissue-selective estrogen complex; Tissue-selective estrogen complexes; Type 2 diabetes; UCPs, uncoupling proteins; VO2, oxygen consumption; WAT, white adipose tissue.
تواريخ الأحداث: Date Created: 20140318 Date Completed: 20140317 Latest Revision: 20220409
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC3953695
DOI: 10.1016/j.molmet.2013.12.009
PMID: 24634829
قاعدة البيانات: MEDLINE
الوصف
تدمد:2212-8778
DOI:10.1016/j.molmet.2013.12.009