دورية أكاديمية
Hepatitis B virus nucleic acid amplification testing of Australian blood donors highlights the complexity of confirming occult hepatitis B virus infection.
| العنوان: | Hepatitis B virus nucleic acid amplification testing of Australian blood donors highlights the complexity of confirming occult hepatitis B virus infection. |
|---|---|
| المؤلفون: | Kiely P; Australian Red Cross Blood Service, Melbourne, Australia., Margaritis AR, Seed CR, Yang H |
| مؤلفون مشاركون: | Australian Red Cross Blood Service NAT Study Group |
| المصدر: | Transfusion [Transfusion] 2014 Aug; Vol. 54 (8), pp. 2084-91. Date of Electronic Publication: 2014 Mar 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association Of Blood Banks Country of Publication: United States NLM ID: 0417360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-2995 (Electronic) Linking ISSN: 00411132 NLM ISO Abbreviation: Transfusion Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Arlington, Va. : American Association Of Blood Banks |
| مواضيع طبية MeSH: | Donor Selection* , Nucleic Acid Amplification Techniques*, DNA, Viral/*blood , Hepatitis B/*blood , Hepatitis B Antibodies/*blood , Hepatitis B Surface Antigens/*blood , Hepatitis B virus/*isolation & purification , Viremia/*diagnosis, Adult ; Algorithms ; Asymptomatic Diseases ; Australia/epidemiology ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B Core Antigens/immunology ; Hepatitis B virus/genetics ; Hepatitis B, Chronic/blood ; Hepatitis B, Chronic/diagnosis ; Humans ; Prevalence ; Risk ; Time Factors ; Viral Load ; Viremia/epidemiology |
| مستخلص: | Background: We present an analysis of the first 2 years of hepatitis B virus (HBV) nucleic acid testing (NAT) of the Australian donor population. Study Design and Methods: Between July 5, 2010, and July 4, 2012, all blood donations were screened for HBV DNA and hepatitis B surface antigen (HBsAg). Donors who tested HBsAg negative but HBV NAT positive were assessed as occult hepatitis B infections (OBI) if reactive for antibodies to HBV core antigen (anti-HBc). Donors who were anti-HBc reactive but with nonrepeatable or nondiscriminated NAT results were assessed as HBV inconclusive pending follow-up testing. Results: During the study period a total of 2,673,521 donations were screened for HBV. Forty-two chronic OBI infections (5.55/100,000 donors) were identified compared to eight acute serologic window period infections (1.06/100,000 donors). Of the 42 OBI cases, 23 (54.8%) were detected the first time they were screened for HBV DNA while 19 (45.2%) gave one or more HBV NAT-nonreactive results before detection. Of 68 donors initially assessed as HBV inconclusive and available for follow-up, 10 later confirmed as OBI cases while 51 were NAT nonreactive but remained anti-HBc reactive and OBI could not be excluded. Conclusion: This study demonstrated a substantially higher prevalence of OBI compared to acute serologic window period HBV infections in Australian blood donors. Follow-up testing of OBI cases indicates that HBV DNA is often only intermittently detectable in OBI, highlighting the importance of including anti-HBc to optimize the HBV testing algorithm. (© 2014 The Authors. Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.) |
| المشرفين على المادة: | 0 (DNA, Viral) 0 (Hepatitis B Antibodies) 0 (Hepatitis B Core Antigens) 0 (Hepatitis B Surface Antigens) |
| تواريخ الأحداث: | Date Created: 20140322 Date Completed: 20141014 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/trf.12556 |
| PMID: | 24650170 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-2995 |
|---|---|
| DOI: | 10.1111/trf.12556 |