دورية أكاديمية
أعرض في EDS

Downregulation of GABAA receptor protein subunits α6, β2, δ, ε, γ2, θ, and ρ2 in superior frontal cortex of subjects with autism.

التفاصيل البيبلوغرافية
العنوان: Downregulation of GABAA receptor protein subunits α6, β2, δ, ε, γ2, θ, and ρ2 in superior frontal cortex of subjects with autism.
المؤلفون: Fatemi SH; Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN, 55455, USA, fatem002@umn.edu., Reutiman TJ, Folsom TD, Rustan OG, Rooney RJ, Thuras PD
المصدر: Journal of autism and developmental disorders [J Autism Dev Disord] 2014 Aug; Vol. 44 (8), pp. 1833-45.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 7904301 Publication Model: Print Cited Medium: Internet ISSN: 1573-3432 (Electronic) Linking ISSN: 01623257 NLM ISO Abbreviation: J Autism Dev Disord Subsets: MEDLINE
أسماء مطبوعة: Publication: <2006- >: New York, NY : Springer
Original Publication: New York, Plenum Press.
مواضيع طبية MeSH: Down-Regulation*, Autistic Disorder/*metabolism , Frontal Lobe/*metabolism , Receptors, GABA-A/*genetics, Adult ; Animals ; Autistic Disorder/genetics ; Case-Control Studies ; Cerebellum/metabolism ; Female ; Gene Expression ; Humans ; Male ; Parietal Lobe/metabolism ; Protein Subunits/genetics ; Protein Subunits/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Real-Time Polymerase Chain Reaction ; Receptors, GABA-A/metabolism ; Young Adult ; gamma-Aminobutyric Acid/metabolism
مستخلص: We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABAA) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABAA and GABAB subunits and overall reduced protein expression for GABAA receptor alpha 6 (GABRα6), GABAA receptor beta 2 (GABRβ2), GABAA receptor delta (GABRδ), GABAA receptor epsilon (GABRε), GABAA receptor gamma 2 (GABRγ2), GABAA receptor theta (GABRθ), and GABAA receptor rho 2 (GABRρ2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABAA&B subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism.
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معلومات مُعتمدة: 3R01HD052074-03S1 United States HD NICHD NIH HHS; 5R01HD052074-01A2 United States HD NICHD NIH HHS; R24 MH068855 United States MH NIMH NIH HHS
المشرفين على المادة: 0 (Protein Subunits)
0 (RNA, Messenger)
0 (Receptors, GABA-A)
56-12-2 (gamma-Aminobutyric Acid)
تواريخ الأحداث: Date Created: 20140327 Date Completed: 20141020 Latest Revision: 20211021
رمز التحديث: 20240829
DOI: 10.1007/s10803-014-2078-x
PMID: 24668190
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-3432
DOI:10.1007/s10803-014-2078-x