دورية أكاديمية
A double-blind evaluation of the effect of amlodipine on ambulatory blood pressure in hypertensive patients.
| العنوان: | A double-blind evaluation of the effect of amlodipine on ambulatory blood pressure in hypertensive patients. |
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| المؤلفون: | Mroczek WJ; Cardiovascular Center of Northern Virginia, Falls Church 22044., Burris JF, Allenby KS |
| المصدر: | Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 1988; Vol. 12 Suppl 7, pp. S79-84. |
| نوع المنشور: | Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Print Cited Medium: Print ISSN: 0160-2446 (Print) Linking ISSN: 01602446 NLM ISO Abbreviation: J Cardiovasc Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, Raven Press. |
| مواضيع طبية MeSH: | Blood Pressure/*drug effects , Calcium Channel Blockers/*therapeutic use , Hypertension/*drug therapy , Nifedipine/*analogs & derivatives, Amlodipine ; Clinical Trials as Topic ; Double-Blind Method ; Humans ; Hypertension/physiopathology ; Nifedipine/therapeutic use ; Pulse/drug effects ; Random Allocation ; Time Factors |
| مستخلص: | Amlodipine is a new long-acting calcium antagonist that has a long half-life and appears to be suitable for once-daily administration. A double-blind, randomized, parallel, placebo-controlled study was conducted to evaluate the effect of amlodipine on ambulatory blood pressures in hypertensive patients. The study consisted of a 4-week single-blind placebo run-in phase, followed by 4 weeks of double-blind therapy. Ambulatory blood pressure was measured for 24 h at the end of the placebo run-in phase and after double-blind therapy. Sixteen patients were randomized to receive either amlodipine 5 mg or placebo in a 2:1 ratio. Amlodipine 5 mg daily significantly reduced supine and standing blood pressure 24 h postdose. Ambulatory blood pressure recordings revealed adequate blood pressure control throughout the 24-h dosing interval. Amlodipine was well tolerated and only two patients reported side effects--neither was withdrawn from therapy. No treatment-related abnormalities were noted. It was concluded that amlodipine 5 mg daily was effective antihypertensive therapy throughout the 24-h dosing period in the patients studied, and it was well tolerated. |
| المشرفين على المادة: | 0 (Calcium Channel Blockers) 1J444QC288 (Amlodipine) I9ZF7L6G2L (Nifedipine) |
| تواريخ الأحداث: | Date Created: 19880101 Date Completed: 19890511 Latest Revision: 20220318 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/00005344-198812007-00018 |
| PMID: | 2467136 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0160-2446 |
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| DOI: | 10.1097/00005344-198812007-00018 |