دورية أكاديمية
Molecular profiling of breast cancer in Nigerian women identifies an altered p53 pathway as a major mechanism underlying its poor prognosis compared with British counterpart.
| العنوان: | Molecular profiling of breast cancer in Nigerian women identifies an altered p53 pathway as a major mechanism underlying its poor prognosis compared with British counterpart. |
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| المؤلفون: | Agboola AO; Olabisi Onabanjo University, Department of Morbid Anatomy and Histopathology, Sagamu. johndeji2001@yahoo.co.uk., Banjo AA, Anunobi CC, Ayoade BA, Deji-Agboola AM, Musa AA, Abdel-Fatah T, Nolan CC, Rakha EA, Ellis IO, Green AR |
| المصدر: | The Malaysian journal of pathology [Malays J Pathol] 2014 Apr; Vol. 36 (1), pp. 3-17. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academy of Medicine of Malyasia, College of Pathologists Country of Publication: Malaysia NLM ID: 8101177 Publication Model: Print Cited Medium: Print ISSN: 0126-8635 (Print) Linking ISSN: 01268635 NLM ISO Abbreviation: Malays J Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: June 2000- : Kuala Lumpur : Academy of Medicine of Malyasia, College of Pathologists Original Publication: Kuala Lumpur : Malaysian Society of Pathologists. |
| مواضيع طبية MeSH: | Breast Neoplasms*/ethnology , Breast Neoplasms*/metabolism , Breast Neoplasms*/mortality, Biomarkers, Tumor/*metabolism , Black People/*statistics & numerical data , Tumor Suppressor Protein p53/*metabolism , White People/*statistics & numerical data, Animals ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Nigeria/epidemiology ; Prognosis ; United Kingdom/epidemiology |
| مستخلص: | Background: Advances in breast cancer (BC) research have demonstrated differences between black and white women with regarding tumour behaviour, patient outcome and response to treatment which can be explained by underlying genetic changes. The tumour suppressor gene p53 has been speculated to be involved in tumour biology of triple negative and/or basal -like BC and more commonly observed in black than caucasian women. Materials and Methods: In this study, the protein expression of p53 was investigated in tissue samples from a series of 308 Nigerian women, prepared as a tissue microarray (TMA), using immunohistochemistry. Clinicopathological parameters, biomarkers of functional significance in BC and patient outcome of tumours expressing p53 in Nigerian women were correlated with UK grade matched series. Results: A significantly large proportion of BC from Nigerian women showed high p53 expression compared with UK women (p<0.001). In those tumours showing positive p53 in the Nigerian series, a significant proportion were premenopausal, diagnosed before 50 years, larger in size, with evidence of metastasis into lymphatic vessels ( all p<0.001). In addition, p53 positive expression was also significantly correlated with negative expression of ER and PgR (p<0.001, p<0.03 respectively), BRCA1, MDM2 (all p<0.001), p21 (p=0.006) and E-cadherin (p=0.001) and positively associated with P-cadherin (p=0.001), triple negative phenotype, basal cytokeratin (CK) 5/6 expression (p<0.04) and basal phenotype compared with the UK series (p<0.001). Survival analyses showed Nigerian women with BC were significantly associated with poor BC specific survival (p<0.001, but no significant association with disease free interval was observed. Conclusion: In this study, protein expressions of p53 pathways are different between Nigerian and UK BC women and this may also contribute to differences in tumour biology. Therefore, targeting these p53 pathways for therapeutic usage might improve the poor outcome observed in Black Nigerian women. |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) 0 (TP53 protein, human) 0 (Tumor Suppressor Protein p53) |
| تواريخ الأحداث: | Date Created: 20140426 Date Completed: 20140821 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| PMID: | 24763230 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0126-8635 |
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