دورية أكاديمية

Non-coding RNAs and gastric cancer.

التفاصيل البيبلوغرافية
العنوان: Non-coding RNAs and gastric cancer.
المؤلفون: Li PF; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China., Chen SC; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China., Xia T; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China., Jiang XM; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China., Shao YF; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China., Xiao BX; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China., Guo JM; Pei-Fei Li, Sheng-Can Chen, Tian Xia, Xiao-Ming Jiang, Yong-Fu Shao, Bing-Xiu Xiao, Jun-Ming Guo, Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, Zhejiang Province, China.
المصدر: World journal of gastroenterology [World J Gastroenterol] 2014 May 14; Vol. 20 (18), pp. 5411-9.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
Original Publication: Beijing : WJG Press, c1998-
مواضيع طبية MeSH: RNA, Untranslated/*metabolism , Stomach Neoplasms/*metabolism, Animals ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/metabolism ; RNA, Long Noncoding/metabolism ; RNA, Small Interfering/metabolism ; RNA, Untranslated/genetics ; Signal Transduction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology
مستخلص: Non-coding RNAs (ncRNAs) play key roles in development, proliferation, differentiation and apoptosis. Altered ncRNA expression is associated with gastric cancer occurrence, invasion, and metastasis. Moreover, aberrant expression of microRNAs (miRNAs) is significantly related to gastric cancer tumor stage, size, differentiation and metastasis. MiRNAs interrupt cellular signaling pathways, inhibit the activity of tumor suppressor genes, and affect the cell cycle in gastric cancer cells. Some miRNAs, including miR-21, miR-106a and miR-421, could be potential markers for the diagnosis of gastric cancer. Long non-coding RNAs (lncRNAs), a new research hotspot among cancer-associated ncRNAs, play important roles in epigenetic, transcriptional and post-transcriptional regulation. Several gastric cancer-associated lncRNAs, such as CCAT1, GACAT1, H19, and SUMO1P3, have been explored. In addition, Piwi-interacting RNAs, another type of small ncRNA that is recognized by gastroenterologists, are involved in gastric carcinogenesis, and piR-651/823 represents an efficient diagnostic biomarker of gastric cancer that can be detected in the blood and gastric juice. Small interfering RNAs also function in post-transcriptional regulation in gastric cancer and might be useful in gastric cancer treatment.
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فهرسة مساهمة: Keywords: Gastric cancer; Long non-coding RNA; MicroRNA; Non-coding RNA; Piwi-interacting RNA; Small interfering RNA
المشرفين على المادة: 0 (MicroRNAs)
0 (RNA, Long Noncoding)
0 (RNA, Small Interfering)
0 (RNA, Untranslated)
تواريخ الأحداث: Date Created: 20140517 Date Completed: 20150409 Latest Revision: 20220408
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4017056
DOI: 10.3748/wjg.v20.i18.5411
PMID: 24833871
قاعدة البيانات: MEDLINE