دورية أكاديمية
Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension.
العنوان: | Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension. |
---|---|
المؤلفون: | Blanch GT; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.)., Freiria-Oliveira AH; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.)., Speretta GF; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.)., Carrera EJ; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.)., Li H; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.)., Speth RC; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.)., Colombari E; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.)., Sumners C; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.). deborac@foar.unesp.br csumners@ufl.edu., Colombari DS; From the Department of Physiology and Pathology, School of Dentistry, São Paulo State University, Araraquara, São Paulo, Brazil (G.T.B., A.H.F.-O., G.F.F.S., E.C., D.S.A.C.); Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL (E.J.C., R.C.S.); School of Biotechnology, Southern Medical University, Guangzhou, China (H.L.); and Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville (C.S., R.C.S.). deborac@foar.unesp.br csumners@ufl.edu. |
المصدر: | Hypertension (Dallas, Tex. : 1979) [Hypertension] 2014 Oct; Vol. 64 (4), pp. 777-83. Date of Electronic Publication: 2014 Jun 23. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]- |
مواضيع طبية MeSH: | Gene Expression*, Hypertension, Renovascular/*genetics , Receptor, Angiotensin, Type 2/*genetics , Solitary Nucleus/*metabolism , Vagus Nerve/*metabolism, Angiotensin-Converting Enzyme 2 ; Animals ; Dependovirus/genetics ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Hypertension, Renovascular/metabolism ; Male ; Microscopy, Fluorescence ; Peptidyl-Dipeptidase A/genetics ; Rats ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1/genetics ; Reverse Transcriptase Polymerase Chain Reaction |
مستخلص: | Angiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin-angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary-vagal complex (nucleus of the solitary tract/dorsal motor nucleus of the vagus), a key brain stem region for cardiovascular regulation, on the development of renovascular hypertension. Holtzman normotensive rats were implanted with a silver clip around the left renal artery to induce 2-kidney 1-clip renovascular hypertension. Three weeks later, rats were microinjected in the solitary-vagal complex with either an adenoassociated virus to increase the expression of angiotensin type 2 receptors or with a control vector. We observed that increasing angiotensin type 2 receptor expression in the solitary-vagal complex attenuated the development of renovascular hypertension and also reversed the impairment of the baroreflex and the increase in the low-frequency component of systolic blood pressure observed in renovascular hypertensive rats. Furthermore, an observed decrease in mRNA levels of angiotensin-converting enzyme 2 in the solitary-vagal complex of renovascular hypertensive rats was restored to control levels after viral-mediated increases in angiotensin type 2 receptors at this site. Collectively, these data demonstrate specific and beneficial effects of angiotensin type 2 receptors via the brain of hypertensive rats and suggest that central angiotensin type 2 receptors may be a potential target for therapeutics in renovascular hypertension. (© 2014 American Heart Association, Inc.) |
References: | Nature. 1995 Oct 26;377(6551):748-50. (PMID: 7477267) Cardiovasc Res. 2011 Dec 1;92(3):401-8. (PMID: 21952934) Hypertension. 2008 Feb;51(2):521-7. (PMID: 18086951) Brain Res. 1992 May 15;580(1-2):317-24. (PMID: 1504808) Exp Physiol. 2008 May;93(5):694-700. (PMID: 18356558) Front Neuroendocrinol. 1997 Oct;18(4):383-439. (PMID: 9344632) Am J Physiol Endocrinol Metab. 2000 Mar;278(3):E357-74. (PMID: 10710489) Hypertension. 1991 May;17(5):707-19. (PMID: 2022413) Am J Physiol. 1998 Nov;275(5):R1611-9. (PMID: 9791081) Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1679-84. (PMID: 11959631) J Hypertens. 2000 Jul;18(7):955-61. (PMID: 10930194) J Exp Med. 1934 Feb 28;59(3):347-79. (PMID: 19870251) News Physiol Sci. 1998 Aug;13:170-176. (PMID: 11390784) J Hypertens. 1991 Dec;9(12):1127-33. (PMID: 1663968) J Vasc Surg. 2002 Sep;36(3):443-51. (PMID: 12218965) Cardiovasc Res. 2013 Jan 1;97(1):153-60. (PMID: 22997157) J Hypertens. 2000 Dec;18(12):1841-8. (PMID: 11132609) N Engl J Med. 1999 Apr 29;340(17):1360-1. (PMID: 10219074) Am J Hypertens. 2009 May;22(5):484-92. (PMID: 19229193) Br J Pharmacol. 2010 Feb 1;159(3):709-16. (PMID: 20128808) Kidney Int. 2013 Nov;84(5):931-9. (PMID: 23823602) Hypertension. 2002 Nov;40(5):735-41. (PMID: 12411470) Clin Exp Pharmacol Physiol. 1995 Sep;22(9):665-9. (PMID: 8542682) Hypertension. 2004 Feb;43(2):306-11. (PMID: 14707159) Hypertension. 2005 Aug;46(2):333-40. (PMID: 16009784) Curr Hypertens Rep. 2013 Feb;15(1):31-8. (PMID: 23212695) Circulation. 1999 May 18;99(19):2537-42. (PMID: 10330385) Auton Neurosci. 2014 Jul;183:23-9. (PMID: 24560525) Hypertension. 1990 Feb;15(2 Suppl):I45-50. (PMID: 2298476) Exp Physiol. 2011 Feb;96(2):94-103. (PMID: 21097645) Physiol Rev. 1994 Apr;74(2):323-64. (PMID: 8171117) Hypertension. 2011 Dec;58(6):1057-65. (PMID: 22025374) PLoS One. 2013 Jun 06;8(6):e64788. (PMID: 23762254) J Endocrinol. 2013 Jan 18;216(2):R1-R17. (PMID: 23092879) Neuropharmacology. 1993 Jun;32(6):581-9. (PMID: 8336821) Am J Hypertens. 2011 Jun;24(6):724-30. (PMID: 21394088) Hypertension. 1983 Nov-Dec;5(6 Pt 3):V90-3. (PMID: 6360885) Hypertension. 1986 Aug;8(8):700-5. (PMID: 3733215) |
معلومات مُعتمدة: | R01 HL076803 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: angiotensin II; angiotensin receptor blockers; angiotensin-converting enzyme 2; baroreflex |
المشرفين على المادة: | 0 (Receptor, Angiotensin, Type 1) 0 (Receptor, Angiotensin, Type 2) 147336-22-9 (Green Fluorescent Proteins) EC 3.4.15.1 (Peptidyl-Dipeptidase A) EC 3.4.17.23 (Ace2 protein, rat) EC 3.4.17.23 (Angiotensin-Converting Enzyme 2) |
تواريخ الأحداث: | Date Created: 20140625 Date Completed: 20141121 Latest Revision: 20211021 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4162765 |
DOI: | 10.1161/HYPERTENSIONAHA.114.03188 |
PMID: | 24958505 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!