دورية أكاديمية
Lack of correlation of BTNL2 polymorphism and cancer risk in sarcoidosis. BTNL2 and cancer risk in sarcoidosis.
| العنوان: | Lack of correlation of BTNL2 polymorphism and cancer risk in sarcoidosis. BTNL2 and cancer risk in sarcoidosis. |
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| المؤلفون: | Gaillot-Drevon M; Service de Pneumologie A Hospices Civils de Lyon centre hospitalier Lyon Sud 165Ch du grand Revoyet 69495 Pierre Benite France. maud.gaillot-drevon@chu-lyon.fr., Calender A, Blay JY, Valeyre D, Israel-Biet D, Roy P, Pacheco Y |
| المصدر: | Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG [Sarcoidosis Vasc Diffuse Lung Dis] 2014 Jul 08; Vol. 31 (2), pp. 136-41. Date of Electronic Publication: 2014 Jul 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mattioli 1885 Country of Publication: Italy NLM ID: 9610928 Publication Model: Electronic Cited Medium: Internet ISSN: 2532-179X (Electronic) Linking ISSN: 11240490 NLM ISO Abbreviation: Sarcoidosis Vasc Diffuse Lung Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : Parma, Italy : Mattioli 1885 Original Publication: Cormano, Milan, Italy : PCA Pub., c1996- |
| مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Membrane Glycoproteins/*genetics , Neoplasms/*genetics , Sarcoidosis/*genetics, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Butyrophilins ; Case-Control Studies ; Female ; France ; Gene Frequency ; Genetic Predisposition to Disease ; Heterozygote ; Homozygote ; Humans ; Logistic Models ; Male ; Middle Aged ; Neoplasms/diagnosis ; Neoplasms/immunology ; Odds Ratio ; Phenotype ; Risk Assessment ; Risk Factors ; Sarcoidosis/complications ; Sarcoidosis/diagnosis ; Sarcoidosis/immunology ; Young Adult |
| مستخلص: | Background: Sarcoidosis is a polygenic immune disorder disease with predominant manifestations in the lung. BTNL2 gene polymorphisms were previously linked to susceptibility to sarcoidosis. Relationships between sarcoidosis and cancers have been suspected for a long time but little evidence has been reported until now, and recent works show a link between butyrophilin family proteins and anti tumor immunity. Methods: We studied the polymorphism of the rs2076530 SNP of BTNL2 gene in 35 patients with sarcoidosis and cancer compared to 340 sarcoidosis without cancer, 271 controls and 32 cancer matched controls. Results: We found no association between BTNL2 genotype and cancer risk in sarcoidosis (OR: 2,34; CI95%: 1,30 - 4,20; p = 0,15). Sarcoidosis is associated with the rs2076530SNP of BTNL2 gene. The AA genotype is significantly associated with a 3 more increased risk of sarcoidosis compared to the GG genotype in a co-dominant model (OR: 3,22; CI95%: 2,58 - 4,06; p < 0.0001). The AG genotype is associated with a 1,8 more increased risk (OR: 1,79; CI95%: 1,42 - 2,26). Conclusions: These results confirm the association of BTNL2 rs2076530SNP with the susceptibility to develop sarcoidosis, but not with an increased risk of cancer in these patients. |
| المشرفين على المادة: | 0 (BTNL2 protein, human) 0 (Butyrophilins) 0 (Membrane Glycoproteins) |
| تواريخ الأحداث: | Date Created: 20140801 Date Completed: 20160607 Latest Revision: 20161125 |
| رمز التحديث: | 20231215 |
| PMID: | 25078641 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2532-179X |
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