دورية أكاديمية
أعرض في EDS

Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression.

التفاصيل البيبلوغرافية
العنوان: Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression.
المؤلفون: Yang T; Department of Hepatobiliary Surgery, The First Hospital of Shijiazhuang City, Shijiazhuang, China., Li XN, Li L, Wu QM, Gao PZ, Wang HL, Zhao W
المصدر: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2014 Nov; Vol. 35 (11), pp. 11199-207. Date of Electronic Publication: 2014 Aug 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 8409922 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0380 (Electronic) Linking ISSN: 10104283 NLM ISO Abbreviation: Tumour Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : Amsterdam, The Netherlands : IOS Press
Original Publication: Tokyo, Japan : Saikon Pub. Co., c1984-
مواضيع طبية MeSH: Cell Movement* , Cell Proliferation*, Carcinoma, Hepatocellular/*pathology , Kinesins/*genetics , Liver Neoplasms/*pathology , Oncogene Proteins/*genetics , SOXF Transcription Factors/*metabolism, Adult ; Apoptosis ; Blotting, Western ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Chromatin Immunoprecipitation ; Disease Progression ; Female ; Humans ; Kinesins/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Luciferases/metabolism ; Male ; Middle Aged ; Oncogene Proteins/metabolism ; Promoter Regions, Genetic/genetics ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; SOXF Transcription Factors/antagonists & inhibitors ; SOXF Transcription Factors/genetics ; Tumor Cells, Cultured
مستخلص: Sox17, an antagonist of canonical Wnt/β-catenin signaling, inhibits several malignant carcinogenesis and progression. However, little is known about Sox17 in hepatocellular carcinoma (HCC). Here, we found that Sox17 is downregulated in HCC tissue. Furthermore, Sox17 inhibits cell proliferation and migration in HCC. KIF14, a member of kinesin superfamily protein (KIFs), is an oncogene in a variety of malignant tumors including HCC. We demonstrated that Sox17 is negatively related to KIF14 expression in HCC tissue and Sox17 inhibits HCC cell proliferation and migration by transcriptional downregulation of KIF14 expression. Our results may provide a strategy for blocking HCC carcinogenesis and progression.
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المشرفين على المادة: 0 (Oncogene Proteins)
0 (RNA, Messenger)
0 (RNA, Small Interfering)
0 (SOX17 protein, human)
0 (SOXF Transcription Factors)
EC 1.13.12.- (Luciferases)
EC 3.6.1.- (KIF14 protein, human)
EC 3.6.4.4 (Kinesins)
تواريخ الأحداث: Date Created: 20140810 Date Completed: 20150417 Latest Revision: 20211203
رمز التحديث: 20240829
DOI: 10.1007/s13277-014-2398-7
PMID: 25106407
قاعدة البيانات: MEDLINE
الوصف
تدمد:1423-0380
DOI:10.1007/s13277-014-2398-7