دورية أكاديمية
Cytotoxic constituents from the rhizomes of Curcuma zedoaria.
| العنوان: | Cytotoxic constituents from the rhizomes of Curcuma zedoaria. |
|---|---|
| المؤلفون: | Ahmed Hamdi OA; Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia., Syed Abdul Rahman SN; Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia., Awang K; Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia., Abdul Wahab N; Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Biology Division, Center for Foundation Studies in Science, University of Malaya, 50603 Kuala Lumpur, Malaysia., Looi CY; Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia., Thomas NF; Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia., Abd Malek SN; Center for Natural Products and Drugs Discovery (CENAR), University of Malaya, 50603 Kuala Lumpur, Malaysia ; Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. |
| المصدر: | TheScientificWorldJournal [ScientificWorldJournal] 2014; Vol. 2014, pp. 321943. Date of Electronic Publication: 2014 Jul 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 101131163 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-744X (Electronic) Linking ISSN: 1537744X NLM ISO Abbreviation: ScientificWorldJournal Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Hindawi Publishing Corporation Original Publication: Boynton Beach, FL : Scientific World, Inc., c2001- |
| مواضيع طبية MeSH: | Breast Neoplasms/*drug therapy , Cell Proliferation/*drug effects , Curcuma/*chemistry , Phytotherapy/*methods , Plant Extracts/*pharmacology , Rhizome/*chemistry, Analysis of Variance ; Chromatography, Thin Layer ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Indonesia ; MCF-7 Cells ; Malaysia ; Microscopy, Fluorescence ; Molecular Structure ; Plant Extracts/chemistry ; Plant Extracts/therapeutic use ; Tetrazolium Salts ; Thiazoles |
| مستخلص: | Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including cancer. The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of Curcuma zedoaria rhizomes was tested on two human cancer cell lines (Ca Ski and MCF-7) and a noncancer cell line (HUVEC) using MTT assay. Investigation on the chemical components in the hexane and dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 dial (1), dehydrocurdione (2), curcumenone (3), comosone II (4), curcumenol (5), procurcumenol (6), germacrone (7), zerumbone epoxide (8), zederone (9), 9-isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.0(1,5)]undec-6-en-8-ol (10), furanodiene (11), germacrone-4,5-epoxide (12), calcaratarin A (13), isoprocurcumenol (14), germacrone-1,10-epoxide (15), zerumin A (16), curcumanolide A (17), curcuzedoalide (18), and gweicurculactone (19). Compounds (1-19) were evaluated for their antiproliferative effect using MTT assay against four cancer cell lines (Ca Ski, MCF-7, PC-3, and HT-29). Curcumenone (3) and curcumenol (5) displayed strong antiproliferative activity (IC50 = 8.3 ± 1.0 and 9.3 ± 0.3 μg/mL, resp.) and were found to induce apoptotic cell death on MCF-7 cells using phase contrast and Hoechst 33342/PI double-staining assay. Thus, the present study provides basis for the ethnomedical application of Curcuma zedoaria in the treatment of breast cancer. |
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| المشرفين على المادة: | 0 (Plant Extracts) 0 (Tetrazolium Salts) 0 (Thiazoles) EUY85H477I (thiazolyl blue) |
| تواريخ الأحداث: | Date Created: 20140816 Date Completed: 20151026 Latest Revision: 20220318 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4121215 |
| DOI: | 10.1155/2014/321943 |
| PMID: | 25126594 |
| قاعدة البيانات: | MEDLINE |
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