دورية أكاديمية
Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes.
العنوان: | Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. |
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المؤلفون: | Tarlow BD; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA; Department of Pediatrics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address: tarlowb@ohsu.edu., Pelz C; Department of Pediatrics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA., Naugler WE; Department of Gastroenterology & Hepatology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA., Wakefield L; Department of Pediatrics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA., Wilson EM; Yecuris Corporation, P.O. box 4645, Tualatin, OR 97062, USA., Finegold MJ; Department of Pathology, Baylor College of Medicine, 6621 Fannin Street, Houston, TX 77030, USA., Grompe M; Department of Pediatrics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. |
المصدر: | Cell stem cell [Cell Stem Cell] 2014 Nov 06; Vol. 15 (5), pp. 605-18. Date of Electronic Publication: 2014 Oct 09. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, MA : Cell Press |
مواضيع طبية MeSH: | Adult Stem Cells/*cytology , Hepatocytes/*pathology , Liver/*pathology, Adult Stem Cells/metabolism ; Adult Stem Cells/ultrastructure ; Animals ; Biomarkers/metabolism ; Cell Differentiation ; Cell Separation ; Cellular Microenvironment ; Clone Cells ; Gene Expression Regulation ; Hepatic Duct, Common/cytology ; Hepatocytes/ultrastructure ; Humans ; Mesoderm/metabolism ; Mice, Inbred C57BL ; SOX9 Transcription Factor/metabolism |
مستخلص: | Adult liver progenitor cells are biliary-like epithelial cells that emerge only under injury conditions in the periportal region of the liver. They exhibit phenotypes of both hepatocytes and bile ducts. However, their origin and their significance to injury repair remain unclear. Here, we used a chimeric lineage tracing system to demonstrate that hepatocytes contribute to the progenitor pool. RNA-sequencing, ultrastructural analysis, and in vitro progenitor assays revealed that hepatocyte-derived progenitors were distinct from their biliary-derived counterparts. In vivo lineage tracing and serial transplantation assays showed that hepatocyte-derived proliferative ducts retained a memory of their origin and differentiated back into hepatocytes upon cessation of injury. Similarly, human hepatocytes in chimeric mice also gave rise to biliary progenitors in vivo. We conclude that human and mouse hepatocytes can undergo reversible ductal metaplasia in response to injury, expand as ducts, and subsequently contribute to restoration of the hepatocyte mass. (Copyright © 2014 Elsevier Inc. All rights reserved.) |
التعليقات: | Comment in: Nature. 2015 Jan 8;517(7533):155-6. (PMID: 25567279) |
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معلومات مُعتمدة: | F30-DK09551 United States DK NIDDK NIH HHS; R01-DK051592 United States DK NIDDK NIH HHS; R01 DK051592 United States DK NIDDK NIH HHS; F30 DK095514 United States DK NIDDK NIH HHS; P30 DK056338 United States DK NIDDK NIH HHS; P01-DK044080 United States DK NIDDK NIH HHS; P30 CA069533 United States CA NCI NIH HHS; T32 GM071338 United States GM NIGMS NIH HHS; T32 DK007202 United States DK NIDDK NIH HHS |
سلسلة جزيئية: | GEO GSE55552; GSE58679 |
المشرفين على المادة: | 0 (Biomarkers) 0 (SOX9 Transcription Factor) |
تواريخ الأحداث: | Date Created: 20141015 Date Completed: 20150716 Latest Revision: 20220419 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4254170 |
DOI: | 10.1016/j.stem.2014.09.008 |
PMID: | 25312494 |
قاعدة البيانات: | MEDLINE |
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