دورية أكاديمية
أعرض في EDS

Sphincter preservation in distal CT2N0 rectal cancer after preoperative chemoradiotherapy.

التفاصيل البيبلوغرافية
العنوان: Sphincter preservation in distal CT2N0 rectal cancer after preoperative chemoradiotherapy.
المؤلفون: Wasserberg N; Department of Surgery B, Petach Tikva, 49100, Israel. nirw@clalit.org.il., Kundel Y; Davidoff Cancer Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, 49100, Israel. yuliak@clalit.org.il.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. yuliak@clalit.org.il., Purim O; Davidoff Cancer Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, 49100, Israel. oferp@clalit.org.il.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. oferp@clalit.org.il., Keidar A; Department of Surgery B, Petach Tikva, 49100, Israel. keidar66@yahoo.com., Kashtan H; Department of Surgery B, Petach Tikva, 49100, Israel. hkashtan@clalit.org.il., Sadot E; Department of Surgery B, Petach Tikva, 49100, Israel. sadote@mskcc.org., Fenig E; Davidoff Cancer Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, 49100, Israel. efenig@clalit.org.il.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. efenig@clalit.org.il., Brenner B; Davidoff Cancer Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, 49100, Israel. brennerb@clalit.org.il.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel. brennerb@clalit.org.il.
المصدر: Radiation oncology (London, England) [Radiat Oncol] 2014 Oct 22; Vol. 9, pp. 233. Date of Electronic Publication: 2014 Oct 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101265111 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-717X (Electronic) Linking ISSN: 1748717X NLM ISO Abbreviation: Radiat Oncol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2006-
مواضيع طبية MeSH: Chemoradiotherapy* , Organ Sparing Treatments*, Adenocarcinoma/*therapy , Anal Canal/*surgery , Rectal Neoplasms/*therapy, Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Anal Canal/physiology ; Digestive System Surgical Procedures ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoadjuvant Therapy ; Preoperative Care ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology ; Retrospective Studies
مستخلص: Background: Preoperative chemoradiotherapy is usually not indicated for cT2N0 rectal cancer. Abdominoperineal resection is the standard treatment for distal rectal tumors. The aim of the study was to evaluate the actual sphincter-preservation rate in patients with distal cT2N0 rectal cancer given neoadjuvant chemoradiotherapy.
Methods: Data were retrospectively collected for all patients who were diagnosed with distal cT2N0 rectal cancer at a tertiary medical center in 2000-2008 and received chemoradiotherapy followed by surgery (5-7 weeks later).
Results: Thirty-three patients (22 male) of median age 65 years (range, 32-88) were identified. Tumor distance from the anal verge ranged from 0 to 5 cm. R0 resection with sphincter preservation was accomplished in 22 patients (66%), with a 22% pathological complete response rate. Median follow-up time was 62 months (range 7-120). There were no local failures. Crude disease-free and overall survival were 82% and 86%, respectively. Factors associated with sphincter preservation were tumor location (OR=0.58, p=0.02, 95% CI=0.37-0.91) and pathological downstaging (OR=7.8, p=0.02, 95% CI=1.35-45.85). Chemoradiotherapy was well tolerated.
Conclusion: High rates of sphincter preservation can be achieved after preoperative chemoradiotherapy for distal cT2N0 rectal cancer, with tolerable toxicity, without compromising oncological outcome.
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تواريخ الأحداث: Date Created: 20141024 Date Completed: 20160128 Latest Revision: 20211021
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC4215010
DOI: 10.1186/s13014-014-0233-3
PMID: 25338839
قاعدة البيانات: MEDLINE
الوصف
تدمد:1748-717X
DOI:10.1186/s13014-014-0233-3