دورية أكاديمية
أعرض في EDS

Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy.

التفاصيل البيبلوغرافية
العنوان: Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy.
المؤلفون: Iwajomo OH; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom; Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi., Moons P; Department of Pediatrics, University of Malawi College of Medicine, Blantyre, Malawi., Nkhata R; Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi., Mzinza D; Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi., Ogunniyi AD; Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, Australia., Williams NA; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom., Heyderman RS; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom; Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi., Finn A; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom. Electronic address: adam.finn@bristol.ac.uk.
المصدر: The Journal of infection [J Infect] 2015 Jun; Vol. 70 (6), pp. 616-23. Date of Electronic Publication: 2014 Nov 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders Country of Publication: England NLM ID: 7908424 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2742 (Electronic) Linking ISSN: 01634453 NLM ISO Abbreviation: J Infect Subsets: MEDLINE
أسماء مطبوعة: Publication: Kent, UK : W.B. Saunders
Original Publication: London, New York, Academic Press.
مواضيع طبية MeSH: B-Lymphocytes/*immunology , HIV Infections/*immunology , Pneumococcal Infections/*immunology , Streptococcus pneumoniae/*immunology, Antiretroviral Therapy, Highly Active ; CD4-Positive T-Lymphocytes/immunology ; Child ; Child, Preschool ; Enzyme-Linked Immunospot Assay ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Immunophenotyping ; Lymphocyte Count ; Malawi ; Male ; Pneumococcal Infections/complications ; Viral Load
مستخلص: Objective: Despite CD4(+) count restoration and viral load suppression with antiretroviral therapy (ART), HIV-infected children remain at increased risk of life-threatening infections including invasive pneumococcal disease (IPD). We therefore investigated whether persistent susceptibility to IPD following ART is associated with incomplete recovery of B-cell function.
Methods: 41 HIV-infected Malawian children commencing ART were followed-up for a 1 year period during which time blood samples were collected at 0, 3, 6 and 12 months for comprehensive immunophenotyping and pneumomococcal-specific Memory B-cell Enzyme-Linked Immunospot assays. In addition, nasopharyngeal swab samples were cultured to determine pneumococcal carriage rates.
Results: Normalization of major lymphocyte subsets such as CD4(+) percentages was evident following 3 months of ART. The proportions of mature naïve B cells (CD19(+) CD10(-) CD27(-) CD21(hi)) and resting memory B cells (CD19(+) CD27(+) CD21(hi)) increased and apoptosis-prone mature activated B cells (CD19(+) CD21(lo) CD10(-)) decreased markedly by 12 months. However, in the context of high nasopharyngeal pneumococcal carriage rates (83%), restoration of pneumococcal protein antigen-specific B-cell memory was more delayed.
Conclusions: These data show that, in chronically HIV-infected children receiving ART, improvement in B-cell memory profiles and function is slower than CD4(+) T-cells. This supports early initiation of ART and informs research into optimal timing of immunization with pneumococcal vaccines.
(Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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معلومات مُعتمدة: 100890 United Kingdom Wellcome Trust; 101113 United Kingdom Wellcome Trust; 083603/A/07/Z United Kingdom Wellcome Trust; 084679/Z/08/Z United Kingdom Wellcome Trust
فهرسة مساهمة: Keywords: Antiretroviral therapy; Children; ELISPOT; HIV; Malawi; Memory B cells; Pneumococcal infection
تواريخ الأحداث: Date Created: 20141203 Date Completed: 20170417 Latest Revision: 20240322
رمز التحديث: 20240322
مُعرف محوري في PubMed: PMC4441108
DOI: 10.1016/j.jinf.2014.10.011
PMID: 25452037
قاعدة البيانات: MEDLINE
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