دورية أكاديمية
أعرض في EDS

Small high-density lipoprotein is associated with monocyte subsets in stable coronary artery disease.

التفاصيل البيبلوغرافية
العنوان: Small high-density lipoprotein is associated with monocyte subsets in stable coronary artery disease.
المؤلفون: Krychtiuk KA; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria., Kastl SP; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria., Pfaffenberger S; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria., Pongratz T; Krankenanstalten Dr. Dostal, Vienna, Austria., Hofbauer SL; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria., Wonnerth A; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria., Katsaros KM; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria., Goliasch G; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria., Gaspar L; 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia., Huber K; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria; 3rd Medical Department, Wilhelminenhospital, Vienna, Austria., Maurer G; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria., Dostal E; Krankenanstalten Dr. Dostal, Vienna, Austria., Oravec S; Krankenanstalten Dr. Dostal, Vienna, Austria; 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia., Wojta J; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Cluster for Cardiovascular Research, Vienna, Austria; Core Facilities, Medical University of Vienna, Vienna, Austria. Electronic address: johann.wojta@meduniwien.ac.at., Speidl WS; Department of Internal Medicine II - Division of Cardiology, Medical University of Vienna, Vienna, Austria. Electronic address: walter.speidl@meduniwien.ac.at.
المصدر: Atherosclerosis [Atherosclerosis] 2014 Dec; Vol. 237 (2), pp. 589-96. Date of Electronic Publication: 2014 Oct 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier
Original Publication: Amsterdam, Elsevier.
مواضيع طبية MeSH: Coronary Artery Disease/*blood , Lipoproteins, HDL/*blood , Monocytes/*cytology, Aged ; Atherosclerosis ; Atorvastatin ; Blood Pressure ; Coronary Angiography ; Cross-Sectional Studies ; Female ; Fluorobenzenes/therapeutic use ; Granulocyte Colony-Stimulating Factor/metabolism ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Heptanoic Acids/therapeutic use ; Humans ; Inflammation ; Interleukin-10/metabolism ; Lipids/chemistry ; Macrophage Colony-Stimulating Factor/metabolism ; Male ; Middle Aged ; Pyrimidines/therapeutic use ; Pyrroles/therapeutic use ; Risk Factors ; Rosuvastatin Calcium ; Sulfonamides/therapeutic use
مستخلص: Objective: High-density lipoprotein (HDL) particles are heterogeneous in structure and function and the role of HDL subfractions in atherogenesis is not well understood. It has been suggested that small HDL may be dysfunctional in patients with coronary artery disease (CAD). Monocytes are considered to play a key role in atherosclerotic diseases. Circulating monocytes can be divided into three subtypes according to their surface expression of CD14 and CD16. Our aim was to examine whether monocyte subsets are associated with HDL subfractions in patients with atherosclerosis.
Methods: We included 90 patients with angiographically stable CAD. Monocyte subsets were defined as classical monocytes (CD14++CD16-; CM), intermediate monocytes (CD14++CD16+; IM) and non-classical monocytes (CD14+CD16++; NCM). HDL subfractions were measured by electrophoresis on polyacrylamide gel.
Results: Serum levels of small HDL correlated with circulating pro-inflammatory NCM and showed an inverse relationship to circulating CM independently from other lipid parameters, risk factors, inflammatory parameters or statin treatment regime, respectively. IM were not associated with small HDL. In particular, patients with small HDL levels in the highest tertile showed dramatically increased levels of NCM (14.7 ± 7% vs. 10.7 ± 5% and 10.8 ± 5%; p = 0.006) and a decreased proportion of CM (79.3 ± 7% vs. 83.7 ± 6% and 83.9 ± 6%; p = 0.004) compared to patients in the two lower tertiles. In contrast, intermediate HDL, large HDL and total HDL were not associated with monocyte subset distribution.
Conclusion: Small HDL levels are associated with pro-inflammatory NCM and inversely correlated with CM. This may suggest that small HDL could have dysfunctional anti-inflammatory properties in patients with established CAD.
(Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.)
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فهرسة مساهمة: Keywords: Atherosclerosis; HDL; Inflammation; Monocyte subsets; Monocytes; Small HDL
المشرفين على المادة: 0 (Fluorobenzenes)
0 (Heptanoic Acids)
0 (Lipids)
0 (Lipoproteins, HDL)
0 (Pyrimidines)
0 (Pyrroles)
0 (Sulfonamides)
130068-27-8 (Interleukin-10)
143011-72-7 (Granulocyte Colony-Stimulating Factor)
81627-83-0 (Macrophage Colony-Stimulating Factor)
83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
83MVU38M7Q (Rosuvastatin Calcium)
A0JWA85V8F (Atorvastatin)
تواريخ الأحداث: Date Created: 20141203 Date Completed: 20150821 Latest Revision: 20181202
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4270455
DOI: 10.1016/j.atherosclerosis.2014.10.015
PMID: 25463093
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1484
DOI:10.1016/j.atherosclerosis.2014.10.015