دورية أكاديمية
Longitudinal renal function in pediatric heart transplant recipients: 20-years experience.
| العنوان: | Longitudinal renal function in pediatric heart transplant recipients: 20-years experience. |
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| المؤلفون: | Gupta P; Division of Pediatric Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Rettiganti M, Gossett JM, Gardner M, Bryant JC, Noel TR, Knecht KR |
| المصدر: | Pediatric transplantation [Pediatr Transplant] 2015 Mar; Vol. 19 (2), pp. 182-7. Date of Electronic Publication: 2014 Dec 06. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997- |
| مواضيع طبية MeSH: | Heart Transplantation*, Heart Failure/*surgery , Kidney/*physiology , Renal Insufficiency/*therapy, Adolescent ; Body Surface Area ; Child ; Child, Preschool ; Creatinine/blood ; Extracorporeal Membrane Oxygenation ; Female ; Glomerular Filtration Rate ; Heart-Assist Devices ; Humans ; Immunosuppressive Agents/therapeutic use ; Infant ; Infant, Newborn ; Kidney Function Tests ; Male ; Odds Ratio ; Regression Analysis ; Retrospective Studies ; Transplant Recipients |
| مستخلص: | This study was initiated to assess the temporal trends of renal function, and define risk factors associated with worsening renal function in pediatric heart transplant recipients in the immediate post-operative period. We performed a single-center retrospective study in children ≤18 yr receiving OHT (1993-2012). The AKIN's validated, three-tiered AKI staging system was used to categorize the degree of WRF. One hundred sixty-four patients qualified for inclusion. Forty-seven patients (28%) were classified as having WRF after OHT. Nineteen patients (11%) required dialysis after heart transplantation. There was a sustained and steady improvement in renal function in children following heart transplantation in all age groups, irrespective of underlying disease process. The significant factors associated with risk of WRF included body surface area (OR: 1.89 for 0.5 unit increase, 95% CI: 1.29-2.76, p = 0.001) and use of ECMO prior to and/or after heart transplantation (OR: 3.50, 95% CI: 1.51-8.13, p = 0.004). Use of VAD prior to heart transplantation was not associated with WRF (OR: 0.50, 95% CI: 0.17-1.51, p = 0.22). On the basis of these data, we demonstrate that worsening renal function improves early after orthotopic heart transplantation. (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: children; extracorporeal membrane oxygenation; heart failure; orthotopic heart transplantation; ventricular assist device; worsening renal function |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20141209 Date Completed: 20151204 Latest Revision: 20150127 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1111/petr.12409 |
| PMID: | 25484128 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-3046 |
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| DOI: | 10.1111/petr.12409 |