دورية أكاديمية
أعرض في EDS

Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway.

التفاصيل البيبلوغرافية
العنوان: Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway.
المؤلفون: Chi JQ; College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, People׳s Republic of China; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People׳s Republic of China; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People׳s Republic of China., Teng M; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People׳s Republic of China., Yu ZH; College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, People׳s Republic of China; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People׳s Republic of China., Xu H; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, People׳s Republic of China., Su JW; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People׳s Republic of China; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People׳s Republic of China., Zhao P; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People׳s Republic of China; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People׳s Republic of China., Xing GX; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People׳s Republic of China., Liang HD; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People׳s Republic of China., Deng RG; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People׳s Republic of China., Qu LH; Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, People׳s Republic of China., Zhang GP; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People׳s Republic of China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, People׳s Republic of China. Electronic address: zhanggaiping2003@163.com., Luo J; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, People׳s Republic of China. Electronic address: luojun593@aliyun.com.
المصدر: Virology [Virology] 2015 Feb; Vol. 476, pp. 72-84. Date of Electronic Publication: 2014 Dec 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, Academic Press.
مواضيع طبية MeSH: Signal Transduction*, Latent TGF-beta Binding Proteins/*metabolism , Marek Disease/*metabolism , MicroRNAs/*metabolism , Oncogene Protein p55(v-myc)/*metabolism , RNA, Viral/*metabolism , Transforming Growth Factor beta/*metabolism, Animals ; Base Sequence ; Chickens ; Down-Regulation ; Gene Expression Regulation, Viral ; Host-Pathogen Interactions ; Latent TGF-beta Binding Proteins/genetics ; Marek Disease/genetics ; Marek Disease/virology ; MicroRNAs/genetics ; Molecular Sequence Data ; Oncogene Protein p55(v-myc)/genetics ; RNA, Viral/genetics
مستخلص: Marek's disease virus (MDV) is a representative alpha herpes virus able to induce rapid-onset T-cell lymphoma in its natural host and regarded as an ideal model for the study of virus-induced tumorigenesis. Recent studies have shown that the mdv1-miR-M4-5p, a viral analog of cellular miR-155, is critical for MDV׳s oncogenicity. However, the precise mechanism whereby it was involved in MD lymphomagenesis remained unknown. We have presently identified the host mRNA targets of mdv1-miR-M4-5 and identified the latent TGF-β binding protein 1 (LTBP1) as a critical target for it. We found that during MDV infection, down-regulation of LTBP1 expression by mdv1-miR-M4-5p led to a significant decrease of the secretion and activation of TGF-β1, with suppression of TGF-β signaling and a significant activation of expression of c-Myc, a well-known oncogene which is critical for virus-induced tumorigenesis. Our findings reveal a novel and important mechanism of how mdv1-miR-M4-5p potentially contributes to MDV-induced tumorigenesis.
(Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: LTBP1; MDV; MicroRNA; Oncogenesis; TGF-β signaling; mdv1-miR-M4-5p; miR-155
المشرفين على المادة: 0 (Latent TGF-beta Binding Proteins)
0 (MicroRNAs)
0 (Oncogene Protein p55(v-myc))
0 (RNA, Viral)
0 (Transforming Growth Factor beta)
تواريخ الأحداث: Date Created: 20141222 Date Completed: 20150413 Latest Revision: 20180429
رمز التحديث: 20231215
DOI: 10.1016/j.virol.2014.11.027
PMID: 25528440
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-0341
DOI:10.1016/j.virol.2014.11.027