دورية أكاديمية
Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses.
| العنوان: | Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses. |
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| المؤلفون: | Rades D; Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net., Huttenlocher S; Department of Radiation Oncology, University of Lübeck, Lübeck, Germany., Rudat V; Department of Radiation Oncology, Saad Specialist Hospital, Al Khobar, Saudi Arabia., Hornung D; Department of Radiation Oncology, University Medical Center Eppendorf, Hamburg, Germany., Blanck O; CyberKnife Centre Northern Germany, Güstrow, Germany., Phuong PC; Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam., Khoa MT; Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam., Schild SE; Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A., Fischer D; Department of Gynecology and Obstetrics, University of Lübeck, Lübeck, Germany. |
| المصدر: | Anticancer research [Anticancer Res] 2015 Jan; Vol. 35 (1), pp. 333-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Attiki, Greece : International Institute of Anticancer Research Original Publication: Athens, Greece : Potamitis Press |
| مواضيع طبية MeSH: | Brain Neoplasms/*surgery , Breast Neoplasms/*surgery, Brain Neoplasms/mortality ; Brain Neoplasms/secondary ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Proportional Hazards Models ; Radiosurgery ; Radiotherapy Dosage ; Tumor Burden |
| مستخلص: | Aim: To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer. Patients and Methods: Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated. Results: Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60%, respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40%, respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10). Conclusion: Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy. (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast cancer; brain metastasis; distant brain control; local control; overall survival; radiation dose; radiosurgery |
| تواريخ الأحداث: | Date Created: 20150101 Date Completed: 20150310 Latest Revision: 20141231 |
| رمز التحديث: | 20240829 |
| PMID: | 25550568 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1791-7530 |
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