دورية أكاديمية
أعرض في EDS

The distinct functions of CENP-C and CENP-T/W in centromere propagation and function in Xenopus egg extracts.

التفاصيل البيبلوغرافية
العنوان: The distinct functions of CENP-C and CENP-T/W in centromere propagation and function in Xenopus egg extracts.
المؤلفون: Krizaic I; a Chromosome Dynamics Group ; Molecular Oncology Program ; Spanish National Cancer Research Center (CNIO) ; Madrid , Spain., Williams SJ, Sánchez P, Rodríguez-Corsino M, Stukenberg PT, Losada A
المصدر: Nucleus (Austin, Tex.) [Nucleus] 2015; Vol. 6 (2), pp. 133-43. Date of Electronic Publication: 2015 Jan 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101518322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-1042 (Electronic) Linking ISSN: 19491034 NLM ISO Abbreviation: Nucleus Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, Tex. : Landes Bioscience
مواضيع طبية MeSH: Cell Extracts/*chemistry , Centromere/*metabolism , Chromosomal Proteins, Non-Histone/*metabolism , Ovum/*metabolism , Xenopus/*metabolism , Xenopus Proteins/*metabolism, Animals ; Autoantigens/metabolism ; Centromere Protein A ; Chromatin ; DNA Replication ; Interphase ; Kinetochores/metabolism ; Mitosis ; Models, Biological
مستخلص: The centromere is the chromosomal region in which the kinetochore is assembled to orchestrate chromosome segregation. It is defined by the presence of a histone H3 variant called Centromere Protein A (CENP-A) or CenH3. Propagation of centromere identity entails deposition of new CENP-A upon exit from mitosis in vertebrate cells. A group of 16 proteins that co-immunoprecipitate with CENP-A, the Constitutive Centromere Associated Network or CCAN, contribute to kinetochore assembly and function. For most of them it is still unclear how and when they are recruited to centromeres and whether they have a role in CENP-A deposition. Taking advantage of the Xenopus egg cell-free system, we have addressed these issues for CCAN proteins CENP-C, CENP-T and CENP-W. CENP-C recruitment occurs as soon as sperm DNA, containing CENP-A, is added to the egg extract, and continues after de novo incorporation of CENP-A in early interphase. In contrast, centromeric recruitment of CENP-T occurs in late interphase and precedes that of CENP-W, which occurs in mitosis. Unlike CENP-C, CENP-T and CENP-W do not participate in CENP-A deposition. However, like CENP-C, they play a major role in kinetochore assembly. Depletion of CENP-C results in reduced amount of CENP-T at centromeres, an effect more prominent in mitosis than in interphase. In spite of this, kinetochores can still be assembled under this condition although the recruitment of Ndc80 and Mis12 is decreased. Our results support the existence of 2 pathways for kinetochore assembly directed by CENP-C and CENP-T/W, which can be reconstituted in Xenopus egg extracts.
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فهرسة مساهمة: Keywords: CCAN; CCAN, Constitutive Centromere Associated Network; CENP, centromere protein; CENP-A; CenH3; kinetochore
المشرفين على المادة: 0 (Autoantigens)
0 (CENP-W protein, Xenopus)
0 (CENPC protein, Xenopus)
0 (CENPT protein, Xenopus)
0 (Cell Extracts)
0 (Centromere Protein A)
0 (Chromatin)
0 (Chromosomal Proteins, Non-Histone)
0 (Xenopus Proteins)
0 (centromere protein C)
تواريخ الأحداث: Date Created: 20150109 Date Completed: 20160119 Latest Revision: 20190422
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4615894
DOI: 10.1080/19491034.2014.1003509
PMID: 25569378
قاعدة البيانات: MEDLINE
الوصف
تدمد:1949-1042
DOI:10.1080/19491034.2014.1003509