دورية أكاديمية
Radiofrequency ablation plus drug-eluting beads transcatheter arterial chemoembolization for the treatment of single large hepatocellular carcinoma.
| العنوان: | Radiofrequency ablation plus drug-eluting beads transcatheter arterial chemoembolization for the treatment of single large hepatocellular carcinoma. |
|---|---|
| المؤلفون: | Iezzi R; Department of Bioimaging and Radiological Sciences, Institute of Radiology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy. Electronic address: iezzir@virgilio.it., Pompili M; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., La Torre MF; Department of Bioimaging and Radiological Sciences, Institute of Radiology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Campanale MC; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Montagna M; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Saviano A; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Cesario V; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Siciliano M; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Annicchiarico E; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Agnes S; Department of Surgery, Division of Organ Transplantation, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Giuliante F; Department of Surgery, Hepatobiliary Surgery Unit, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Grieco A; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Rapaccini GL; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., De Gaetano AM; Department of Bioimaging and Radiological Sciences, Institute of Radiology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Gasbarrini A; Department of Internal Medicine, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy., Bonomo L; Department of Bioimaging and Radiological Sciences, Institute of Radiology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy; Division of Medical Oncology, 'A. Gemelli' Hospital - Catholic University, Rome, Italy. |
| مؤلفون مشاركون: | HepatoCATT Study Group for the Multidisciplinary Management of HCC |
| المصدر: | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2015 Mar; Vol. 47 (3), pp. 242-8. Date of Electronic Publication: 2014 Dec 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 100958385 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3562 (Electronic) Linking ISSN: 15908658 NLM ISO Abbreviation: Dig Liver Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Amsterdam : Elsevier Original Publication: Roma, Italy : Editrice gastroenterologica italiana, c2000- |
| مواضيع طبية MeSH: | Carcinoma, Hepatocellular/*diagnosis , Carcinoma, Hepatocellular/*therapy , Catheter Ablation/*methods , Chemoembolization, Therapeutic/*methods , Liver Neoplasms/*diagnosis , Liver Neoplasms/*therapy , Neoplasm Recurrence, Local/*therapy, Aged ; Combined Modality Therapy ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Treatment Outcome |
| مستخلص: | Background: Our aim was to evaluate the effectiveness of the single-step combined therapy with radiofrequency ablation and drug-eluting beads transarterial chemoembolization in single hepatocellular carcinoma (HCC) larger than 3cm. Secondary aim was to compare the results with those obtained in a matched population treated with drug-eluting beads transarterial chemoembolization alone. Methods: 40 consecutive cirrhotic patients with single HCC were prospectively enrolled and treated. Twenty-three patients had tumours between 3 and 5cm (Group A), and 17 larger than 5cm (Group B). Twenty cirrhotic patients with single HCC treated only with chemoembolization formed the control group. Results: Complete response at 1 month was achieved in 32/40 tumours (80%). During follow-up, complete response was maintained in 25 patients (25/40, 62.5%), and this rate was higher in Group A (69.6% vs 53%, p=0.008). The group treated with combined therapy showed a significantly lower 2-year recurrence (48.1% vs 78.2%, p<0.001) and significantly higher survival (91.1% vs 60.6%, p=0.004) than the group treated with chemoembolization alone. Conclusions: Balloon-occluded-radiofrequency ablation plus drug-eluting beads transarterial chemoembolization is an effective treatment of HCC larger than 3cm not amenable to surgical resection, providing better results than transarterial chemoembolization alone. The best results are achieved in tumours up to 5cm. (Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Ablation; Chemoembolization; Combined therapy; HCC; RFA |
| تواريخ الأحداث: | Date Created: 20150112 Date Completed: 20151203 Latest Revision: 20150223 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.dld.2014.12.007 |
| PMID: | 25577299 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1878-3562 |
|---|---|
| DOI: | 10.1016/j.dld.2014.12.007 |