دورية أكاديمية
Outcome of aplastic anaemia in children. A study by the severe aplastic anaemia and paediatric disease working parties of the European group blood and bone marrow transplant.
| العنوان: | Outcome of aplastic anaemia in children. A study by the severe aplastic anaemia and paediatric disease working parties of the European group blood and bone marrow transplant. |
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| المؤلفون: | Dufour C; Clinical and Experimental Haematology Unit, G Gaslini Childrens' Hospital, Genova, Italy., Pillon M, Sociè G, Rovò A, Carraro E, Bacigalupo A, Oneto R, Passweg J, Risitano A, Tichelli A, Peffault de Latour R, Schrezenmeier H, Hocshmann B, Peters C, Kulasekararaj A, Van Biezen A, Samarasinghe S, Hussein AA, Ayas M, Aljurf M, Marsh J |
| المصدر: | British journal of haematology [Br J Haematol] 2015 May; Vol. 169 (4), pp. 565-73. Date of Electronic Publication: 2015 Feb 14. |
| نوع المنشور: | Comparative Study; Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Databases, Factual* , Hematopoietic Stem Cell Transplantation* , Immunosuppression Therapy*, Anemia, Aplastic/*mortality , Anemia, Aplastic/*therapy , Graft Rejection/*mortality , Graft vs Host Disease/*mortality, Allografts ; Child ; Child, Preschool ; Disease-Free Survival ; Europe/epidemiology ; Female ; Graft Rejection/therapy ; Graft vs Host Disease/therapy ; Humans ; Infant ; Infant, Newborn ; Male ; Survival Rate |
| مستخلص: | This study analysed the outcome of 563 Aplastic Anaemia (AA) children aged 0-12 years reported to the Severe Aplastic Anaemia Working Party database of the European Society for Blood and Marrow Transplantation, according to treatment received. Overall survival (OS) after upfront human leucocyte antigen-matched family donor (MFD) haematopoietic stem cell transplantation (HSCT) or immunosuppressive treatment (IST) was 91% vs. 87% (P 0·18). Event-free survival (EFS) after upfront MFD HSCT or IST was 87% vs. 33% (P 0·001). Ninety-one of 167 patients (55%) failed front-line IST and underwent rescue HSCT. The OS of this rescue group was 83% compared with 91% for upfront MFD HSCT patients and 97% for those who did not fail IST up-front (P 0·017). Rejection was 2% for MFD HSCT and HSCT post-IST failure (P 0·73). Acute graft-versus-host disease (GVHD) grade II-IV was 8% in MFD graft vs. 25% for HSCT post-IST failure (P < 0·0001). Chronic GVHD was 6% in MFD HSCT vs. 20% in HSCT post-IST failure (P < 0·0001). MFD HSCT is an excellent therapy for children with AA. IST has a high failure rate, but remains a reasonable first-line choice if MFD HSCT is not available because high OS enables access to HSCT, which is a very good rescue option. (© 2015 John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: aplastic anaemia; children; haematopoietic stem cell transplantation; immunosuppression |
| تواريخ الأحداث: | Date Created: 20150217 Date Completed: 20150629 Latest Revision: 20211203 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/bjh.13297 |
| PMID: | 25683884 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2141 |
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| DOI: | 10.1111/bjh.13297 |