دورية أكاديمية
أعرض في EDS

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling.

التفاصيل البيبلوغرافية
العنوان: Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling.
المؤلفون: Lin MI; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Price EN; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Boatman S; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Hagedorn EJ; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Trompouki E; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Satishchandran S; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Carspecken CW; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Uong A; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., DiBiase A; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Yang S; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Canver MC; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Dahlberg A; Pediatric Oncology, Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, United States., Lu Z; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, United States., Zhang CC; Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, United States., Orkin SH; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States., Bernstein ID; Pediatric Oncology, Clinical Division, Fred Hutchinson Cancer Research Center, Seattle, United States., Aster JC; Department of Pathology, Brigham and Women's Hospital, Boston, United States., White RM; Department of Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, United States., Zon LI; Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston's Children's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, United States.
المصدر: ELife [Elife] 2015 Feb 25; Vol. 4. Date of Electronic Publication: 2015 Feb 25.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Angiopoietins/*genetics , Hematopoietic Stem Cells/*metabolism , Receptors, Notch/*genetics , Signal Transduction/*genetics , Zebrafish Proteins/*genetics, Angiopoietin-Like Protein 1 ; Angiopoietin-Like Protein 2 ; Angiopoietin-like Proteins ; Angiopoietins/metabolism ; Animals ; Animals, Genetically Modified ; Blotting, Western ; Cells, Cultured ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; HEK293 Cells ; Hematopoiesis/genetics ; Humans ; K562 Cells ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Mice ; Microscopy, Confocal ; Protein Binding ; RNA Interference ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Receptors, Notch/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Time-Lapse Imaging ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/metabolism ; Zebrafish Proteins/metabolism
مستخلص: Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show that angptl2 overexpression is sufficient to expand definitive HSPCs in zebrafish embryos. Angptl1/2 are required for definitive hematopoiesis and vascular specification of the hemogenic endothelium. The loss-of-function phenotype is reminiscent of the notch mutant mindbomb (mib), and a strong genetic interaction occurs between angptls and notch. Overexpressing angptl2 rescues mib while overexpressing notch rescues angptl1/2 morphants. Gene expression studies in ANGPTL2-stimulated CD34(+) cells showed a strong MYC activation signature and myc overexpression in angptl1/2 morphants or mib restored HSPCs formation. ANGPTL2 can increase NOTCH activation in cultured cells and ANGPTL receptor interacted with NOTCH to regulate NOTCH cleavage. Together our data provide insight to the angptl-mediated notch activation through receptor interaction and subsequent activation of myc targets.
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معلومات مُعتمدة: 5R01DK53298 United States DK NIDDK NIH HHS; R01 CA172268 United States CA NCI NIH HHS; U01 HL100395 United States HL NHLBI NIH HHS; 1R01CA172268 United States CA NCI NIH HHS; P50 NS040828 United States NS NINDS NIH HHS; P30 DK049216 United States DK NIDDK NIH HHS; K08AR055368 United States AR NIAMS NIH HHS; 5R01HL048801-21 United States HL NHLBI NIH HHS; 5P01HL32262-32 United States HL NHLBI NIH HHS; K08 AR055368 United States AR NIAMS NIH HHS; P01 HL032262 United States HL NHLBI NIH HHS; 5U01HL10001-05 United States HL NHLBI NIH HHS; P30 HD018655 United States HD NICHD NIH HHS; Canada Canadian Institutes of Health Research; R01 HL048801 United States HL NHLBI NIH HHS; R24 DK092760 United States DK NIDDK NIH HHS; United States Howard Hughes Medical Institute; R24DK092760-02 United States DK NIDDK NIH HHS; 5P30DK49216-19 United States DK NIDDK NIH HHS; P50-NS40828 United States NS NINDS NIH HHS; R01 DK053298 United States DK NIDDK NIH HHS; P30-HD18655 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: LILRB2; angiopoietin-like proteins; developmental biology; hematopoietic stem and progenitor cells; myc; notch; stem cells; zebrafish
سلسلة جزيئية: GEO GSE51652; GSE63010
المشرفين على المادة: 0 (ANGPTL2 protein, human)
0 (Angiopoietin-Like Protein 1)
0 (Angiopoietin-Like Protein 2)
0 (Angiopoietin-like Proteins)
0 (Angiopoietins)
0 (Angptl1 protein, zebrafish)
0 (LILRB2 protein, human)
0 (Membrane Glycoproteins)
0 (Receptors, Immunologic)
0 (Receptors, Notch)
0 (Zebrafish Proteins)
0 (angptl2b protein, zebrafish)
تواريخ الأحداث: Date Created: 20150226 Date Completed: 20160120 Latest Revision: 20211203
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4371382
DOI: 10.7554/eLife.05544
PMID: 25714926
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.05544