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أعرض في EDS

The role of contrast-enhanced ultrasound (CEUS) in visualizing atherosclerotic carotid plaque vulnerability: which injection protocol? Which scanning technique?

التفاصيل البيبلوغرافية
العنوان: The role of contrast-enhanced ultrasound (CEUS) in visualizing atherosclerotic carotid plaque vulnerability: which injection protocol? Which scanning technique?
المؤلفون: Iezzi R; Department of Bioimaging and Radiological Sciences, Institute of Radiology, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168 Rome, Italy. Electronic address: roberto.iezzi@rm.unicatt.it., Petrone G; Institute of Pathology, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168, Rome, Italy., Ferrante A; Department of Vascular Surgery, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168 Rome, Italy., Lauriola L; Institute of Pathology, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168, Rome, Italy., Vincenzoni C; Department of Vascular Surgery, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168 Rome, Italy., la Torre MF; Department of Bioimaging and Radiological Sciences, Institute of Radiology, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168 Rome, Italy., Snider F; Department of Vascular Surgery, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168 Rome, Italy., Rindi G; Institute of Pathology, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168, Rome, Italy., Bonomo L; Department of Bioimaging and Radiological Sciences, Institute of Radiology, 'A. Gemelli' Hospital-Catholic University, L.go A Gemelli 8, 00168 Rome, Italy.
المصدر: European journal of radiology [Eur J Radiol] 2015 May; Vol. 84 (5), pp. 865-71. Date of Electronic Publication: 2015 Feb 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Science Ireland Ltd
Original Publication: Stuttgart ; New York : Thieme, [c1981-
مواضيع طبية MeSH: Contrast Media*, Carotid Stenosis/*diagnostic imaging , Plaque, Atherosclerotic/*surgery, Aged ; Carotid Stenosis/surgery ; Endarterectomy, Carotid ; Female ; Humans ; Injections ; Male ; Middle Aged ; Phospholipids ; Predictive Value of Tests ; Prospective Studies ; Sensitivity and Specificity ; Sulfur Hexafluoride ; Ultrasonography/methods
مستخلص: Purpose: To correlate the degree of plaque vulnerability as determined by contrast-enhanced ultrasound (CEUS) with histological findings. Secondary objectives were to optimize the CEUS acquisition technique and image evaluation methods.
Materials and Methods: Fifty consecutive patients, either symptomatic and asymptomatic referring to our department in order to perform carotid endarterectomy (TEA), were enrolled. Each patient provided informed consent before undergoing CEUS. Ultrasound examination was performed using high-frequency (8-14 MHz) linear probe and a non-linear pulse inversion technique (mechanical index: 0.09-1.3). A double contrast media injection (Sonovue, 2 mL and 4 mL; Bracco, Italy) was performed. Two videotapes were recorded for every injection: early "dynamic" phase and late "flash" phase, performed with 6 high mechanical index impulses. Movies were quantitatively and qualitatively evaluated. Qualitative and quantitative evaluation were statistically compared to immunohistological diagnosis of vulnerable plaque, considered as gold standard.
Results: Qualitative CEUS evaluation obtained high statistical results when compared to immunohistological results, with values of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of 94%, 68%, 87%, 85% and 86%, respectively, which became higher if considering only asymptomatic patient, with a NPV of 91%. Nevertheless, quantitative software evaluation proved less effective and could not reach similar results.
Conclusion: Carotid plaque enhancement assessed with CEUS well correlates with histological assessment of plaque instability. CEUS may provide valuable information for plaque risk stratification and may play a role in the indication to treatment of patients with carotid stenoses, particularly in asymptomatic population.
(Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: CEUS; Carotid plaque; Dynamic imaging; Late-phase imaging; Vulnerable plaque
المشرفين على المادة: 0 (Contrast Media)
0 (Phospholipids)
0 (contrast agent BR1)
WS7LR3I1D6 (Sulfur Hexafluoride)
تواريخ الأحداث: Date Created: 20150227 Date Completed: 20151103 Latest Revision: 20181202
رمز التحديث: 20221213
DOI: 10.1016/j.ejrad.2015.01.024
PMID: 25715662
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7727
DOI:10.1016/j.ejrad.2015.01.024