التفاصيل البيبلوغرافية
| العنوان: |
[Progress in the study of Velvet and LaeA proteins and their relation to the development and bioactive compounds in medicinal fungi]. |
| المؤلفون: |
Xu ZC, Sun C, Xu J, Zhang X, Luo HM, Ji AJ, Hu YL, Song JY, Chen SL |
| المصدر: |
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2014 Nov; Vol. 49 (11), pp. 1520-7. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
Chinese |
| بيانات الدورية: |
Publisher: Zhongguo yao xue hui Country of Publication: China NLM ID: 21710340R Publication Model: Print Cited Medium: Print ISSN: 0513-4870 (Print) Linking ISSN: 05134870 NLM ISO Abbreviation: Yao Xue Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Beijing : Zhongguo yao xue hui |
| مواضيع طبية MeSH: |
Fungal Proteins/*metabolism , Fungi/*chemistry, Gene Expression Regulation, Fungal ; Genes, Regulator ; Protein Structure, Tertiary ; Secondary Metabolism ; Structure-Activity Relationship |
| مستخلص: |
The medicinal fungi, which are of great importance in traditional medicine, are facing the problems of wild resources scarcity and low concentration of bioactive compounds. Velvet family and LaeA global regulator play a vital role in secondary metabolism and developmental programs, which are found in a wide variety of fungi ranging from Chytridiomycota to Basidiomycota. This review elaborates the structures and functions between Velvet family and LaeA protein. The Velvet family which shares the Velvet protein domain, including VeA (Velvet), VelB (Velvet like B), VosA (viability of spores A) and VelC (Velvet like C), acts on the regulation function is secondary metabolism and developmental programs such as asexual and sexual development. Furthermore, the function is affected by environmental factors such as light and temperature. LaeA protein which owns S-adenosylmethionine-dependent methyltransferase domain, coordinately regulates development and secondary metabolism by regulating and modifying the Velvet proteins. The regulation of LaeA is mediated by light receptor proteins. Therefore, clarifying the mechanism of Velvet and LaeA proteins in medicinal fungi will pave the way for nurturing medicinal fungi and improving production of bioactive compounds. |
| المشرفين على المادة: |
0 (Fungal Proteins) |
| تواريخ الأحداث: |
Date Created: 20150312 Date Completed: 20160202 Latest Revision: 20181202 |
| رمز التحديث: |
20221213 |
| PMID: |
25757276 |
| قاعدة البيانات: |
MEDLINE |
