دورية أكاديمية
ATG-induced accelerated immune senescence: clinical implications in renal transplant recipients.
| العنوان: | ATG-induced accelerated immune senescence: clinical implications in renal transplant recipients. |
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| المؤلفون: | Crepin T; INSERM, UMR1098, Federation Hospitalo-Universitaire INCREASE, Besançon, France; Université de Franche-Comté, Faculté de Médecine et de Pharmacie, Besançon, France; Structure Fédérative de Recherche, SFR FED4234, Besançon, France; CHU Besançon, Department of Nephrology, Dialysis, and Renal Transplantation, Besançon, France., Carron C, Roubiou C, Gaugler B, Gaiffe E, Simula-Faivre D, Ferrand C, Tiberghien P, Chalopin JM, Moulin B, Frimat L, Rieu P, Saas P, Ducloux D, Bamoulid J |
| المصدر: | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2015 Apr; Vol. 15 (4), pp. 1028-38. Date of Electronic Publication: 2015 Mar 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Original Publication: Copenhagen : Munksgaard International Publishers, 2001- |
| مواضيع طبية MeSH: | Kidney Transplantation*, Antilymphocyte Serum/*immunology, Adult ; Female ; Humans ; Male ; Middle Aged ; T-Lymphocytes/immunology |
| مستخلص: | Persistent ATG-induced CD4(+) T cell lymphopenia is associated with serious clinical complications. We tested the hypothesis that ATG induces accelerated immune senescence in renal transplant recipients (RTR). Immune senescence biomarkers were analyzed at transplant and one-year later in 97 incident RTR -62 patients receiving ATG and 35 receiving anti-CD25 mAb (α-CD25). This consisted in: (i) thymic output; (ii) bone marrow renewal of CD34(+) hematopoietic progenitor cells (CD34(+) HPC) and lymphoid (l-HPC) and myeloid (m-HPC) progenitor ratio; (iii) T cell phenotype; and (iv) measurement of T cell relative telomere length (RTL) and telomerase activity (RTA). Clinical correlates were analyzed with a 3 year follow-up. Thymic output significantly decreased one-year posttransplant in ATG-treated patients. ATG was associated with a significant decrease in l-HPC/m-HPC ratio. Late stage differentiated CD57(+) /CD28(-) T cells increased in ATG-treated patients. One-year posttransplant T cell RTL and RTA were consequently lower in ATG-treated patients. ATG is associated with accelerated immune senescence. Increased frequency of late differentiated CD4(+) T cell frequency at transplantation tended to be predictive of a higher risk of subsequent opportunistic infections and of acute rejection only in ATG-treated patients but this needs confirmation. Considering pretransplant immune profile may help to select those patients who may benefit from ATG to prevent severe infections and acute rejection. (© Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.) |
| فهرسة مساهمة: | Keywords: cell death: senescence; complication; immune deficiency; immunosuppressant; immunosuppressive regimens; induction; polyclonal preparations: rabbit antithymocyte globulin |
| المشرفين على المادة: | 0 (Antilymphocyte Serum) |
| تواريخ الأحداث: | Date Created: 20150312 Date Completed: 20151216 Latest Revision: 20230124 |
| رمز التحديث: | 20230126 |
| DOI: | 10.1111/ajt.13092 |
| PMID: | 25758660 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1600-6143 |
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| DOI: | 10.1111/ajt.13092 |