دورية أكاديمية
Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature.
العنوان: | Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature. |
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المؤلفون: | Khan OF; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Zaia EW; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Jhunjhunwala S; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Xue W; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ‡Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Cai W; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Yun DS; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Barnes CM; ∥Alnylam Pharmaceuticals, Cambridge, Massachusetts 02142, United States., Dahlman JE; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ⊥Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Dong Y; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; §Department of Anesthesiology, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, United States., Pelet JM; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Webber MJ; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Tsosie JK; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Jacks TE; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ‡Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; #Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Langer R; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ⊥Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ∇Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Anderson DG; †Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ⊥Harvard-MIT Division of Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; ∇Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States. |
المصدر: | Nano letters [Nano Lett] 2015 May 13; Vol. 15 (5), pp. 3008-16. Date of Electronic Publication: 2015 Apr 02. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101088070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6992 (Electronic) Linking ISSN: 15306984 NLM ISO Abbreviation: Nano Lett Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c2001- |
مواضيع طبية MeSH: | Gene Transfer Techniques*, Dendrimers/*chemistry , Nanostructures/*chemistry , RNA, Small Interfering/*chemistry, Animals ; Dendrimers/therapeutic use ; Endothelial Cells/drug effects ; Humans ; Lung/drug effects ; Lung/pathology ; Nanostructures/therapeutic use ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use |
مستخلص: | Targeted RNA delivery to lung endothelial cells has the potential to treat conditions that involve inflammation, such as chronic asthma and obstructive pulmonary disease. To this end, chemically modified dendrimer nanomaterials were synthesized and optimized for targeted small interfering RNA (siRNA) delivery to lung vasculature. Using a combinatorial approach, the free amines on multigenerational poly(amido amine) and poly(propylenimine) dendrimers were substituted with alkyl chains of increasing length. The top performing materials from in vivo screens were found to primarily target Tie2-expressing lung endothelial cells. At high doses, the dendrimer-lipid derivatives did not cause chronic increases in proinflammatory cytokines, and animals did not suffer weight loss due to toxicity. We believe these materials have potential as agents for the pulmonary delivery of RNA therapeutics. |
References: | N Engl J Med. 2013 Aug 29;369(9):819-29. (PMID: 23984729) Pharm Res. 2006 Aug;23(8):1868-76. (PMID: 16845585) Cancer Res. 2005 Nov 15;65(22):10280-8. (PMID: 16288016) Science. 2001 Nov 23;294(5547):1708-12. (PMID: 11721053) ACS Nano. 2011 Mar 22;5(3):1877-87. (PMID: 21322531) Proc Assoc Am Physicians. 1998 Nov-Dec;110(6):482-8. (PMID: 9824530) Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3955-60. (PMID: 24516150) Free Radic Biol Med. 2003 Aug 15;35(4):327-40. (PMID: 12899936) ACS Nano. 2009 Dec 22;3(12):4110-6. (PMID: 19919048) Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5181-5. (PMID: 8389472) Nature. 2010 Apr 15;464(7291):1067-70. (PMID: 20305636) Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3553-61. (PMID: 25114235) Cell. 2004 Jul 23;118(2):149-61. (PMID: 15260986) Nature. 1998 Feb 19;391(6669):806-11. (PMID: 9486653) Chest. 1996 Nov;110(5):1143-9. (PMID: 8915211) Nat Nanotechnol. 2014 Aug;9(8):648-55. (PMID: 24813696) Nat Rev Immunol. 2007 Jun;7(6):467-77. (PMID: 17525755) J Clin Endocrinol Metab. 2001 Jun;86(6):2709-16. (PMID: 11397875) Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1864-9. (PMID: 20080679) Angew Chem Int Ed Engl. 2014 Dec 22;53(52):14397-401. (PMID: 25354018) Am J Respir Crit Care Med. 2002 Jan 15;165(2):211-5. (PMID: 11790657) Bioconjug Chem. 2008 Jul;19(7):1448-55. (PMID: 18553894) Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):981-6. (PMID: 20080556) Int Immunopharmacol. 2003 Mar;3(3):319-28. (PMID: 12639809) Biomacromolecules. 2011 Dec 12;12(12):4283-90. (PMID: 22029823) J Cell Sci. 2008 Jul 1;121(Pt 13):2115-22. (PMID: 18565824) Mol Ther Nucleic Acids. 2012 Jan 24;1:e4. (PMID: 23344621) Gene Ther. 2006 Sep;13(18):1360-70. (PMID: 16625242) Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9355-8. (PMID: 8415706) J Drug Target. 2005 Aug;13(7):431-43. (PMID: 16308212) J Am Chem Soc. 2013 Jan 30;135(4):1438-44. (PMID: 23301582) Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8529-33. (PMID: 22782619) Nat Commun. 2014;5:4277. (PMID: 24969323) Mol Ther. 2013 Aug;21(8):1570-8. (PMID: 23799535) Nat Protoc. 2009;4(7):1064-72. (PMID: 19561589) Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12881-6. (PMID: 23882076) Genes Dev. 2001 Jan 15;15(2):188-200. (PMID: 11157775) |
معلومات مُعتمدة: | U54 CA151884 United States CA NCI NIH HHS; K99 CA169512 United States CA NCI NIH HHS; R00 CA169512 United States CA NCI NIH HHS; United States Howard Hughes Medical Institute; 1K99CA169512 United States CA NCI NIH HHS |
فهرسة مساهمة: | Keywords: in vivo; modified dendrimer nanoparticles; nanomaterial; siRNA; target lung endothelial cells |
المشرفين على المادة: | 0 (Dendrimers) 0 (RNA, Small Interfering) |
تواريخ الأحداث: | Date Created: 20150320 Date Completed: 20160204 Latest Revision: 20200930 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4825876 |
DOI: | 10.1021/nl5048972 |
PMID: | 25789998 |
قاعدة البيانات: | MEDLINE |
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