دورية أكاديمية
Young-age prostate cancer.
| العنوان: | Young-age prostate cancer. |
|---|---|
| المؤلفون: | Hussein S; Department of Laboratory Medicine, Kuwait Cancer Control Center, Kuwait, Kuwait., Satturwar S; Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Van der Kwast T; Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. |
| المصدر: | Journal of clinical pathology [J Clin Pathol] 2015 Jul; Vol. 68 (7), pp. 511-5. Date of Electronic Publication: 2015 Apr 02. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0376601 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-4146 (Electronic) Linking ISSN: 00219746 NLM ISO Abbreviation: J Clin Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : BMJ Pub. Group Original Publication: London : British Medical Association |
| مواضيع طبية MeSH: | Prostatic Neoplasms*/ethnology , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology, Adult ; Age of Onset ; BRCA2 Protein/genetics ; Biomarkers, Tumor/genetics ; Genetic Predisposition to Disease ; Heredity ; Homeodomain Proteins/genetics ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Grading ; Phenotype ; Prevalence ; Risk Factors |
| مستخلص: | Although prostate cancer is a disease of the elderly, its diagnosis is not uncommonly made in men younger than 55 years. Both ethnic, familial and genetic factors play a role in the early onset of prostate cancer, but the biology, particularly of low-grade prostate cancers detected at young age is not well understood. Autopsy studies have shown a high prevalence of Gleason score 6 prostate cancers in men under 55 years, but mortality of prostate cancer at this young age is almost negligible. Recently, a number of susceptibility genes such as BRCA2 and HOXB13 were reported, each with their own specific biological and histopathology features. In this review, we provide an update on the most recent findings in young-age prostate cancer. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.) |
| فهرسة مساهمة: | Keywords: EPIDEMIOLOGY; GENETICS; UROGENITAL PATHOLOGY |
| المشرفين على المادة: | 0 (BRCA2 Protein) 0 (BRCA2 protein, human) 0 (Biomarkers, Tumor) 0 (HOXB13 protein, human) 0 (Homeodomain Proteins) |
| تواريخ الأحداث: | Date Created: 20150404 Date Completed: 20150901 Latest Revision: 20220311 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1136/jclinpath-2015-202993 |
| PMID: | 25837493 |
| قاعدة البيانات: | MEDLINE |
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