دورية أكاديمية
أعرض في EDS

Environmentally Realistic Doses of Cadmium as a Possible Etiologic Agent for Idiopathic Pathologies.

التفاصيل البيبلوغرافية
العنوان: Environmentally Realistic Doses of Cadmium as a Possible Etiologic Agent for Idiopathic Pathologies.
المؤلفون: Leite R; Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil., Peloso EF; Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil., Gadelha FR; Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil. frgad@unicamp.br., Dolder MA; Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brazil.
المصدر: Biological trace element research [Biol Trace Elem Res] 2015 Nov; Vol. 168 (1), pp. 133-40. Date of Electronic Publication: 2015 Apr 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London, Clifton, N. J.] Humana Press.
مواضيع طبية MeSH: Antioxidants/*metabolism , Cadmium/*analysis , Cadmium Poisoning/*complications , Environmental Exposure/*adverse effects, Animals ; Cadmium Poisoning/epidemiology ; Cadmium Poisoning/pathology ; Endothelium, Vascular/drug effects ; Fertilizers/analysis ; Glutathione/metabolism ; Leydig Cells/pathology ; Lipid Peroxidation/drug effects ; Male ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Testis/metabolism ; Testis/pathology ; Weight Gain/drug effects
مستخلص: Cadmium is a heavy metal of increasing environmental concern that has long been associated to several human pathological processes. Recent population surveys have correlated cadmium non-occupational exposure to widespread idiopathic pathologies. Food and tobacco are reported to be the main exposure sources of cadmium to the general population, as phosphate fertilizers are rich in such a metal, thus contaminating the crops. Although its mechanisms of toxicity are not a consensus in the literature, it is well established that reactive oxygen species play a key role in this process, leading to the oxidation of several biological molecules. We have therefore assessed whether three environmentally realistic doses of cadmium alter the oxidative status of Wistar rat testis and eventually result in histological damages. Our results show that even the lowest environmental dose of cadmium was able to disturb the endogenous antioxidant system in Wistar testis, although an increase in lipid peroxidation was observed only within the group exposed to the highest environmental dose. Despite that no remarkable morphological changes were observed in any group, significant alterations in blood vessel lumen were reported for some cadmium-exposed animals, suggesting that endothelium is one of the primary targets involved in cadmium toxicity.
فهرسة مساهمة: Keywords: Cadmium; Idiopathic pathologies; Oxidative stress
المشرفين على المادة: 0 (Antioxidants)
0 (Fertilizers)
0 (Reactive Oxygen Species)
00BH33GNGH (Cadmium)
GAN16C9B8O (Glutathione)
تواريخ الأحداث: Date Created: 20150409 Date Completed: 20160726 Latest Revision: 20151010
رمز التحديث: 20240628
DOI: 10.1007/s12011-015-0322-7
PMID: 25850543
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0720
DOI:10.1007/s12011-015-0322-7