دورية أكاديمية
Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19(+) cells in Crohn's disease.
| العنوان: | Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19(+) cells in Crohn's disease. |
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| المؤلفون: | Andreu-Ballester JC; Juan C Andreu-Ballester, Carlos García-Ballesteros, Research Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain., Gil-Borrás R; Juan C Andreu-Ballester, Carlos García-Ballesteros, Research Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain., García-Ballesteros C; Juan C Andreu-Ballester, Carlos García-Ballesteros, Research Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain., Catalán-Serra I; Juan C Andreu-Ballester, Carlos García-Ballesteros, Research Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain., Amigo V; Juan C Andreu-Ballester, Carlos García-Ballesteros, Research Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain., Fernández-Fígares V; Juan C Andreu-Ballester, Carlos García-Ballesteros, Research Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain., Cuéllar C; Juan C Andreu-Ballester, Carlos García-Ballesteros, Research Department, Arnau de Vilanova Hospital, 46015 Valencia, Spain. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2015 Apr 21; Vol. 21 (15), pp. 4666-72. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Tonsillectomy*, Anti-Inflammatory Agents/*therapeutic use , Antibodies, Viral/*immunology , Antigens, CD19/*immunology , Crohn Disease/*drug therapy , Herpesvirus 4, Human/*immunology , Immunoglobulin M/*immunology , Lymphocytes/*drug effects , Mesalamine/*therapeutic use, Adult ; Antibodies, Viral/blood ; Antigens, CD19/blood ; Biomarkers/blood ; Crohn Disease/blood ; Crohn Disease/diagnosis ; Crohn Disease/immunology ; Female ; Humans ; Immunoglobulin M/blood ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Lymphocytes/virology ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Treatment Outcome |
| مستخلص: | Aim: To study anti-Epstein-Barr virus (EBV) IgG antibodies in Crohn's disease in relation to treatment, immune cells, and prior tonsillectomy/appendectomy. Methods: This study included 36 CD patients and 36 healthy individuals (controls), and evaluated different clinical scenarios (new patient, remission and active disease), previous mucosa-associated lymphoid tissue removal (tonsillectomy and appendectomy) and therapeutic regimens (5-aminosalicylic acid, azathioprine, anti-tumor necrosis factor, antibiotics, and corticosteroids). T and B cells subsets in peripheral blood were analyzed by flow cytometry (markers included: CD45, CD4, CD8, CD3, CD19, CD56, CD2, CD3, TCRαβ and TCRγδ) to relate with the levels of anti-EBV IgG antibodies, determined by enzyme-linked immunosorbent assay. Results: The lowest anti-EBV IgG levels were observed in the group of patients that were not in a specific treatment (95.4 ± 53.9 U/mL vs 131.5 ± 46.2 U/mL, P = 0.038). The patients that were treated with 5-aminosalicylic acid showed the highest anti-EBV IgG values (144.3 U/mL vs 102.6 U/mL, P = 0.045). CD19(+) cells had the largest decrease in the group of CD patients that received treatment (138.6 vs 223.9, P = 0.022). The analysis of anti-EBV IgG with respect to the presence or absence of tonsillectomy showed the highest values in the tonsillectomy group of CD patients (169.2 ± 20.7 U/mL vs 106.1 ± 50.3 U/mL, P = 0.002). However, in the group of healthy controls, no differences were seen between those who had been tonsillectomized and subjects who had not been operated on (134.0 ± 52.5 U/mL vs 127.7 ± 48.1 U/mL, P = 0.523). Conclusion: High anti-EBV IgG levels in CD are associated with 5-aminosalicylic acid treatment, tonsillectomy, and decrease of CD19(+) cells. |
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| فهرسة مساهمة: | Keywords: 5-aminosalicylic acid; B cells; Crohn’s disease; Epstein-Barr virus; Tonsillectomy |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Antibodies, Viral) 0 (Antigens, CD19) 0 (Biomarkers) 0 (Immunoglobulin M) 4Q81I59GXC (Mesalamine) |
| تواريخ الأحداث: | Date Created: 20150428 Date Completed: 20160203 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4402315 |
| DOI: | 10.3748/wjg.v21.i15.4666 |
| PMID: | 25914477 |
| قاعدة البيانات: | MEDLINE |
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