دورية أكاديمية
Interferon α/β Receptor-Deficient Mice as a Model for Ebola Virus Disease.
| العنوان: | Interferon α/β Receptor-Deficient Mice as a Model for Ebola Virus Disease. |
|---|---|
| المؤلفون: | Brannan JM; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland., Froude JW; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland., Prugar LI; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland., Bakken RR; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland., Zak SE; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland., Daye SP; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland., Wilhelmsen CE; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland., Dye JM; US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland. |
| المصدر: | The Journal of infectious diseases [J Infect Dis] 2015 Oct 01; Vol. 212 Suppl 2, pp. S282-94. Date of Electronic Publication: 2015 May 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press |
| مواضيع طبية MeSH: | Ebolavirus/*pathogenicity , Hemorrhagic Fever, Ebola/*virology , Receptor, Interferon alpha-beta/*deficiency , Virulence/*physiology, Animals ; Antibodies, Viral/immunology ; Cell Line ; Chlorocebus aethiops ; Disease Models, Animal ; Ebola Vaccines/immunology ; Ebolavirus/metabolism ; Glycoproteins/immunology ; Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Replicon/immunology ; Vaccination/methods ; Vero Cells/virology ; Viral Proteins/immunology ; Viral Proteins/metabolism ; Virulence/immunology |
| مستخلص: | A major obstacle in ebolavirus research is the lack of a small-animal model for Sudan virus (SUDV), as well as other wild-type (WT) ebolaviruses. Here, we expand on research by Bray and by Lever et al suggesting that WT ebolaviruses are pathogenic in mice deficient for the type 1 interferon (IFN) α/β receptor (IFNα/βR-/-). We examined the disease course of several WT ebolaviruses: Boneface (SUDV/Bon) and Gulu variants of SUDV, Ebola virus (EBOV), Bundibugyo virus (BDBV), Taï Forest virus, and Reston virus (RESTV). We determined that exposure to WT SUDV or EBOV results in reproducible signs of disease in IFNα/βR-/- mice, as measured by weight loss and partial lethality. Vaccination with the SUDV or EBOV glycoprotein (GP)-expressing Venezuelan equine encephalitis viral replicon particle vaccine protected these mice from SUDV/Bon and EBOV challenge, respectively. Treatment with SUDV- or EBOV-specific anti-GP antibodies protected mice from challenge when delivered 1-3 days after infection. Serial sampling experiments revealed evidence of disseminated intravascular coagulation in the livers of mice infected with the Boneface variant of SUDV, EBOV, and BDBV. Taken together, these data solidify the IFNα/βR-/- mouse as an important and useful model for the study of WT EBOV disease. (Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.) |
| فهرسة مساهمة: | Keywords: Ebola virus; Ebola virus disease; Sudan virus; coagulopathy; mouse model; pathogenesis |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Ebola Vaccines) 0 (Glycoproteins) 0 (Viral Proteins) 156986-95-7 (Receptor, Interferon alpha-beta) |
| تواريخ الأحداث: | Date Created: 20150507 Date Completed: 20151201 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/infdis/jiv215 |
| PMID: | 25943199 |
| قاعدة البيانات: | MEDLINE |
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