دورية أكاديمية
Growth hormone deficiency in adults impacts left ventricular mechanics: a two-dimensional speckle-tracking study.
| العنوان: | Growth hormone deficiency in adults impacts left ventricular mechanics: a two-dimensional speckle-tracking study. |
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| المؤلفون: | Mihaila S; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania. Electronic address: sorinamihaila@yahoo.com., Mincu RI; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania., Rimbas RC; University & Emergency Hospital Bucharest, Bucharest, Romania., Dulgheru RE; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania., Dobrescu R; Institute of Endocrinology 'C.I. Parhon,' Bucharest, Romania., Magda SL; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania., Badiu C; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania., Vinereanu D; University of Medicine and Pharmacy Carol Davila, Bucharest, Romania. |
| المصدر: | The Canadian journal of cardiology [Can J Cardiol] 2015 Jun; Vol. 31 (6), pp. 752-9. Date of Electronic Publication: 2015 Jan 22. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8510280 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1916-7075 (Electronic) Linking ISSN: 0828282X NLM ISO Abbreviation: Can J Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan./Feb. 2011- : Oxford, UK : Elsevier Original Publication: [Oakville, Ont. : Canadian Cardiology Publications Inc., c1984- |
| مواضيع طبية MeSH: | Image Interpretation, Computer-Assisted*, Echocardiography/*methods , Human Growth Hormone/*deficiency , Hypopituitarism/*complications , Ventricular Dysfunction, Left/*diagnostic imaging , Ventricular Dysfunction, Left/*etiology, Adult ; Aged ; Case-Control Studies ; Deficiency Diseases/complications ; Deficiency Diseases/diagnosis ; Dwarfism, Pituitary/complications ; Dwarfism, Pituitary/diagnosis ; Female ; Follow-Up Studies ; Humans ; Hypopituitarism/diagnosis ; Male ; Middle Aged ; Observer Variation ; Prospective Studies ; Reference Values |
| مستخلص: | Background: Growth hormone deficiency (GHD) in adults is associated with increased cardiovascular events, but detailed assessment of cardiac and vascular function is lacking. Thus we assessed cardiac, arterial, and endothelial functions, using conventional and speckle-tracking echocardiography, in adults with GHD compared with controls with similar cardiovascular risk. Methods: Fifty-two patients with GHD (47 ± 16 years; 34 men) and no cardiovascular disease or diabetes were enrolled prospectively and compared with 50 age- and sex-matched controls. Comprehensive echocardiography was performed in all participants. Regional left ventricular (LV) function was assessed from global longitudinal strain (GLS), global radial strain (GRS), and global circumferential strain (GCS), whereas LV torsion (LVtor) was calculated from basal (RotB) and apical (RotA) rotations. Arterial function was assessed from intima-media thickening, local wave speed, and beta index of stiffness, whereas endothelial function was assessed from flow-mediated dilation. Levels of pro-brain natriuretic peptide (proBNP) were measured. Results: GLS and GCS were decreased more in patients with GHD than in controls (-17.2% ± 2.7% vs. -19.3% ± 3.3% and -15.9% ± 5.4% vs. -18.8% ± 3.5%; both P < 0.01), whereas GRS was similar. RotB and LVtor were also decreased in patients with GHD (-4.8° ± 2.6° vs. -6.2° ± 2.1°/cm and 1.8° ± 0.6° vs. 2.3° ± 1.1°/cm; both P < 0.05). ProBNP was increased in patients with GHD (61.0 ± 74 pg/dL vs. 24.7 ± 21 pg/dL; P = 0.002). Arterial and endothelial functions were similar between groups. Conclusions: In conclusion, adults with GHD had LV longitudinal dysfunction and increased proBNP levels compared with controls, suggesting intrinsic myocardial disease. Further studies are needed to assess if this cardiac impairment in adults with GHD is reversible after GH replacement. (Copyright © 2015 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 12629-01-5 (Human Growth Hormone) |
| SCR Disease Name: | Short Stature, Idiopathic, Autosomal |
| تواريخ الأحداث: | Date Created: 20150530 Date Completed: 20150807 Latest Revision: 20161125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.cjca.2015.01.008 |
| PMID: | 26022988 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1916-7075 |
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| DOI: | 10.1016/j.cjca.2015.01.008 |