دورية أكاديمية
أعرض في EDS

The plasma proteomic signature as a strategic tool for early diagnosis of acute coronary syndrome.

التفاصيل البيبلوغرافية
العنوان: The plasma proteomic signature as a strategic tool for early diagnosis of acute coronary syndrome.
المؤلفون: Laborde CM; Laboratory of Vascular Physiopathology, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain., Alonso-Orgaz S; Laboratory of Vascular Physiopathology, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain., Mourino-Alvarez L; Laboratory of Vascular Physiopathology, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain., Moreu J; Department of Hemodynamic, Hospital Virgen de la Salud, SESCAM, Toledo, Spain., Vivanco F; Department of Immunology, IIS-Fundación Jiménez Diaz, Madrid, Spain ; Department of Biochemistry and Molecular Biology I, Universidad Complutense, Madrid, Spain., Padial LR; Department of Cardiology, Hospital Virgen de la Salud, Toledo, Spain., Barderas MG; Laboratory of Vascular Physiopathology, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain.
المصدر: Proteome science [Proteome Sci] 2014 Oct 10; Vol. 12, pp. 43. Date of Electronic Publication: 2014 Oct 10 (Print Publication: 2014).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101170539 Publication Model: eCollection Cited Medium: Print ISSN: 1477-5956 (Print) Linking ISSN: 14775956 NLM ISO Abbreviation: Proteome Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, c2003-
مستخلص: Background: Acute coronary syndrome is the major cause of death in developed countries. Despite its high prevalence, there is still a strong need for new biomarkers which permit faster and more accurate diagnostics and new therapeutic drugs. The basis for this challenge lay in improving our understanding of the whole atherosclerotic process from atherogenesis to atherothrombosis. In this study, we conducted two different proteomic analyses of peripheral blood plasma from non-ST elevation acute coronary syndrome and ST elevation acute coronary syndrome patients vs healthy controls.
Results: Two-dimensional Fluorescence Difference in Gel Electrophoresis and mass spectrometry permitted the identification of 31 proteins with statistical differences (p < 0.05) between experimental groups. Additionally, validation by Western blot and Selected Reaction Monitoring permitted us to confirm the identification of a different and characteristic plasma proteomic signature for NSTEACS and STEACS patients.
Conclusions: We purpose the severity of hypoxia as the cornerstone for explaining the differences observed between both groups.
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فهرسة مساهمة: Keywords: Acute coronary syndrome; Biomarker; Protein; Two-dimensional fluorescence difference in gel electrophoresis
تواريخ الأحداث: Date Created: 20150604 Date Completed: 20150603 Latest Revision: 20201001
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4451929
DOI: 10.1186/1477-5956-12-43
PMID: 26038678
قاعدة البيانات: MEDLINE
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