دورية أكاديمية
Burden of Clostridium difficile infection between 2010 and 2013: Trends and outcomes from an academic center in Eastern Europe.
| العنوان: | Burden of Clostridium difficile infection between 2010 and 2013: Trends and outcomes from an academic center in Eastern Europe. |
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| المؤلفون: | Kurti Z; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Lovasz BD; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Mandel MD; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Csima Z; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Golovics PA; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Csako BD; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Mohas A; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Gönczi L; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Gecse KB; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Kiss LS; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Szathmari M; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary., Lakatos PL; Zsuzsanna Kurti, Barbara D Lovasz, Michael D Mandel, Zoltan Csima, Petra A Golovics, Bence D Csako, Anna Mohas, Lorant Gönczi, Krisztina B Gecse, Lajos S Kiss, Miklos Szathmari, Peter L Lakatos, 1 Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2015 Jun 07; Vol. 21 (21), pp. 6728-35. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Academic Medical Centers*, Clostridioides difficile/*pathogenicity , Clostridium Infections/*epidemiology , Clostridium Infections/*microbiology, Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/adverse effects ; Case-Control Studies ; Chi-Square Distribution ; Clostridioides difficile/isolation & purification ; Clostridium Infections/diagnosis ; Clostridium Infections/drug therapy ; Clostridium Infections/mortality ; Comorbidity ; Diabetes Mellitus/epidemiology ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Hungary/epidemiology ; Incidence ; Kaplan-Meier Estimate ; Length of Stay ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Patient Readmission ; Prognosis ; Prospective Studies ; Protective Factors ; Proton Pump Inhibitors/adverse effects ; Recurrence ; Risk Factors ; Severity of Illness Index ; Time Factors |
| مستخلص: | Aim: To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection (CDI). Methods: A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May 2013. Two hundred and forty-seven inpatients were prospectively diagnosed with CDI. For the risk analysis a 1:3 matching was used. Data of 732 patients matched for age, sex, and inpatient care period and unit were compared to those of the CDI population. Inpatient records were collected from an electronic hospital database and comprehensively reviewed. Results: Incidence of CDI was 21.0/1000 admissions (2.1% of all-cause hospitalizations and 4.45% of total inpatient days). The incidence of severe CDI was 12.6% (2.63/1000 of all-cause hospitalizations). Distribution of CDI cases was different according to the unit type, with highest incidence rates in hematology, gastroenterology and nephrology units (32.9, 25 and 24.6/1000 admissions, respectively) and lowest rates in 1.4% (33/2312) in endocrinology and general internal medicine (14.2 and 16.9/1000 admissions) units. Recurrence of CDI was 11.3% within 12 wk after discharge. Duration of hospital stay was longer in patients with CDI compared to controls (17.6 ± 10.8 d vs 12.4 ± 7.71 d). CDI accounted for 6.3% of all-inpatient deaths, and 30-d mortality rate was 21.9% (54/247 cases). Risk factors for CDI were antibiotic therapy [including third-generation cephalosporins or fluoroquinolones, odds ratio (OR) = 4.559; P < 0.001], use of proton pump inhibitors (OR = 2.082, P < 0.001), previous hospitalization within 12 mo (OR = 3.167, P < 0.001), previous CDI (OR = 15.32; P < 0.001), while presence of diabetes mellitus was associated with a decreased risk for CDI (OR = 0.484; P < 0.001). Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination (P < 0.001), and antibiotic therapy duration was longer (P < 0.02). Severity, mortality and outcome of primary infections and relapsing cases did not significantly differ. Conclusion: CDI was accounted for significant burden with longer hospitalization and adverse outcomes. Antibiotic, PPI therapy and previous hospitalization or CDI were risk factors for CDI. |
| References: | Curr Opin Gastroenterol. 2014 Jan;30(1):54-62. (PMID: 24285002) PLoS One. 2014;9(6):e98400. (PMID: 24897375) J Chronic Dis. 1987;40(5):373-83. (PMID: 3558716) Eur J Gastroenterol Hepatol. 2014 Aug;26(8):880-7. (PMID: 24942955) PLoS One. 2014;9(7):e102848. (PMID: 25057871) Wien Klin Wochenschr. 2014 Jul;126(13-14):427-30. (PMID: 24903143) Am J Gastroenterol. 2014 Aug;109(8):1265-76. (PMID: 25001255) J Hosp Infect. 2014 Sep;88(1):12-21. (PMID: 24996516) BMJ Open. 2014;4(9):e005665. (PMID: 25186155) Anaerobe. 2014 Dec;30:18-23. (PMID: 25079669) CMAJ. 2004 Aug 31;171(5):466-72. (PMID: 15337727) JAMA. 2005 Dec 21;294(23):2989-95. (PMID: 16414946) Arch Intern Med. 2006 Oct 9;166(18):1945-51. (PMID: 17030826) Curr Opin Gastroenterol. 2007 Jan;23(1):4-9. (PMID: 17133077) Arch Surg. 2007 Jul;142(7):624-31; discussion 631. (PMID: 17638799) Clin Infect Dis. 2007 Dec 15;45(12):1543-9. (PMID: 18190314) Emerg Infect Dis. 2008 Jul;14(7):1031-8. (PMID: 18598621) Infect Control Hosp Epidemiol. 2009 Jun;30(6):526-33. (PMID: 19419272) Clin Gastroenterol Hepatol. 2009 Sep;7(9):981-7. (PMID: 19523534) Infect Control Hosp Epidemiol. 2010 May;31(5):431-55. (PMID: 20307191) Infect Control Hosp Epidemiol. 2010 Oct;31(10):1030-7. (PMID: 20695799) Lancet. 2011 Jan 1;377(9759):63-73. (PMID: 21084111) Infect Control Hosp Epidemiol. 2011 Apr;32(4):387-90. (PMID: 21460491) Curr Opin Gastroenterol. 2012 Jan;28(1):1-9. (PMID: 22134217) MMWR Morb Mortal Wkly Rep. 2012 Mar 9;61(9):157-62. (PMID: 22398844) Clin Infect Dis. 2012 Jul;55(2):216-23. (PMID: 22491338) Clin Infect Dis. 2012 Aug;55 Suppl 2:S88-92. (PMID: 22752870) J Pharm Pract. 2013 Oct;26(5):464-75. (PMID: 24064435) J Antimicrob Chemother. 2013 Dec;68(12):2927-33. (PMID: 23825381) World J Gastroenterol. 2013 Nov 28;19(44):8034-41. (PMID: 24307797) Clin Microbiol Infect. 2014 Mar;20 Suppl 2:1-26. (PMID: 24118601) Tech Coloproctol. 2014 Mar;18(3):223-32. (PMID: 24178946) Curr Med Res Opin. 2014 Jun;30(6):1121-30. (PMID: 24552133) Infect Control Hosp Epidemiol. 2002 Mar;23(3):137-40. (PMID: 11918118) |
| فهرسة مساهمة: | Keywords: Antibiotics; Clostridium difficile infection; Hospitalization; Proton pump inhibitors |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Proton Pump Inhibitors) |
| تواريخ الأحداث: | Date Created: 20150616 Date Completed: 20160318 Latest Revision: 20220331 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC4458783 |
| DOI: | 10.3748/wjg.v21.i21.6728 |
| PMID: | 26074711 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-2840 |
|---|---|
| DOI: | 10.3748/wjg.v21.i21.6728 |