دورية أكاديمية
The expression difference of insulin-like growth factor 1 receptor in breast cancers with or without diabetes.
| العنوان: | The expression difference of insulin-like growth factor 1 receptor in breast cancers with or without diabetes. |
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| المؤلفون: | Xin C, Jing D, Jie T, Wu-Xia L, Meng Q, Ji-Yan L; Department of Medical Oncology, Cancer Center, The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China. |
| المصدر: | Journal of cancer research and therapeutics [J Cancer Res Ther] 2015 Apr-Jun; Vol. 11 (2), pp. 295-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Country of Publication: India NLM ID: 101249598 Publication Model: Print Cited Medium: Internet ISSN: 1998-4138 (Electronic) Linking ISSN: 19984138 NLM ISO Abbreviation: J Cancer Res Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Mumbai, India : Medknow Publications |
| مواضيع طبية MeSH: | Breast Neoplasms/*complications , Breast Neoplasms/*metabolism , Diabetes Mellitus, Type 2/*complications , Receptor, IGF Type 1/*metabolism, Aged ; Aged, 80 and over ; Biomarkers ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; Insulin-Like Growth Factor I/metabolism ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Receptor, IGF Type 1/genetics ; Retrospective Studies ; Signal Transduction ; Tumor Burden |
| مستخلص: | Context: The insulin-like growth factor (IGF) and insulin receptors' (IR) axes play important roles in both breast cancer and diabetes mellitus. Aim: We tend to explore the expression characteristics of proteins in IGF/IR axis in breast cancer with type 2 diabetes mellitus (T2DM). Settings and Design: We conducted a case-control investigation of T2DM and non-diabetes (n = 40, 1:1) in breast cancer patients. Materials and Methods: Some important molecules of IGF/IR axis were detected in breast cancer tissues by immunohistochemical staining. The multivariable analyses of the relationship of clinicopathological characters with the significant molecules were also detected. Statistical Analysis Used: The results were statistically evaluated by Statistical Package for the Social Sciences (SPSS version 17.0) software. Chi-square test and logistic regression are used. Results: Higher expression of IGF 1 receptor (IGF1R) was found in breast cancers of patients with T2DM, compared those without diabetes (P = 0.044). Negative expression of human epidermal growth factor receptor 2 (Her2) was found to be associated with higher expression of IGF1R in the breast cancers of patients with T2DM. There were no differences found in the expression of proteins of IGF-1, IGF-2, IGF-binding protein 3 (IGFBP3), IR, insulin receptor substrate (IRS)-1, IRS-2 and mammalian target of rapamycin (mTOR) between T2DM group and non-diabetes group. Conclusion: Our study found that breast cancer with T2DM had a higher expression of IGF1R, and the higher IGF1R was associated with negative Her2 expression. |
| المشرفين على المادة: | 0 (Biomarkers) 67763-96-6 (Insulin-Like Growth Factor I) EC 2.7.10.1 (Receptor, IGF Type 1) |
| تواريخ الأحداث: | Date Created: 20150708 Date Completed: 20160406 Latest Revision: 20150707 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4103/0973-1482.138195 |
| PMID: | 26148588 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1998-4138 |
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| DOI: | 10.4103/0973-1482.138195 |