دورية أكاديمية
A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity.
| العنوان: | A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity. |
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| المؤلفون: | Osterman IA; a Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology ; Lomonosov Moscow State University ; Moscow , Russia., Evfratov SA; a Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology ; Lomonosov Moscow State University ; Moscow , Russia., Dzama MM; a Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology ; Lomonosov Moscow State University ; Moscow , Russia., Pletnev PI; a Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology ; Lomonosov Moscow State University ; Moscow , Russia., Kovalchuk SI; b Research Institute for Physical-Chemical Medicine of Ministry of Public Health of Russian Federation ; Moscow , Russia., Butenko IO; b Research Institute for Physical-Chemical Medicine of Ministry of Public Health of Russian Federation ; Moscow , Russia., Pobeguts OV; b Research Institute for Physical-Chemical Medicine of Ministry of Public Health of Russian Federation ; Moscow , Russia., Golovina AY; a Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology ; Lomonosov Moscow State University ; Moscow , Russia., Govorun VM; b Research Institute for Physical-Chemical Medicine of Ministry of Public Health of Russian Federation ; Moscow , Russia., Bogdanov AA; a Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology ; Lomonosov Moscow State University ; Moscow , Russia., Sergiev PV; a Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology ; Lomonosov Moscow State University ; Moscow , Russia., Dontsova OA; a Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology ; Lomonosov Moscow State University ; Moscow , Russia. |
| المصدر: | RNA biology [RNA Biol] 2015; Vol. 12 (9), pp. 966-71. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101235328 Publication Model: Print Cited Medium: Internet ISSN: 1555-8584 (Electronic) Linking ISSN: 15476286 NLM ISO Abbreviation: RNA Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Georgetown, TX : Landes Bioscience, |
| مواضيع طبية MeSH: | Gene Expression Regulation* , Peptide Chain Initiation, Translational*, Escherichia coli Proteins/*metabolism , Eukaryotic Initiation Factors/*metabolism , Peptide Initiation Factors/*metabolism , RNA, Messenger/*genetics , RNA, Messenger/*metabolism , Stress, Physiological/*genetics, Escherichia coli/genetics ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Protein Biosynthesis ; Proteome |
| مستخلص: | YciH is a bacterial protein, homologous to eukaryotic translation initiation factor eIF1. Preceding evidence obtained with the aid of in vitro translation initiation system suggested that it may play a role of a translation initiation factor, ensuring selection against suboptimal initiation complexes. Here we studied the effect of Escherichia coli yciH gene inactivation on translation of model mRNAs. Neither the translation efficiency of leaderless mRNAs, nor mRNAs with non AUG start codons, was found to be affected by YciH in vivo. Comparative proteome analysis revealed that yciH gene knockout leads to a more than fold2- increase in expression of 66 genes and a more than fold2- decrease in the expression of 20 genes. Analysis of these gene sets allowed us to suggest a role of YciH as an inhibitor of translation in a stress response rather than the role of a translation initiation factor. |
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| فهرسة مساهمة: | Keywords: initiation factor; initiation fidelity; translation; yciH |
| المشرفين على المادة: | 0 (Escherichia coli Proteins) 0 (Eukaryotic Initiation Factors) 0 (Peptide Initiation Factors) 0 (Proteome) 0 (RNA, Messenger) 0 (YciH protein, E coli) |
| تواريخ الأحداث: | Date Created: 20150716 Date Completed: 20160712 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4615754 |
| DOI: | 10.1080/15476286.2015.1069464 |
| PMID: | 26177339 |
| قاعدة البيانات: | MEDLINE |
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