دورية أكاديمية
[THE COMPARISON OF RESULTS OF DETECTION OF MINIMAL RESIDUAL DISEASE IN PERIPHERAL BLOOD AND MARROW IN CHILDREN OF THE FIRST YEAR OF LIFE WITH ACUTE LYMPHOBLASTIC LEUCOSIS].
| العنوان: | [THE COMPARISON OF RESULTS OF DETECTION OF MINIMAL RESIDUAL DISEASE IN PERIPHERAL BLOOD AND MARROW IN CHILDREN OF THE FIRST YEAR OF LIFE WITH ACUTE LYMPHOBLASTIC LEUCOSIS]. |
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| المؤلفون: | Tsaur GA, Riger TO, Popov AM, Nasedkina TV, Kustanovich AM, Solodovnikov AG, Streneva OV, Shorikov EV, Tsvirenko SV, Saveliev LI, Fechina LG |
| المصدر: | Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2015 Apr; Vol. 60 (4), pp. 14-22. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Meditsina Country of Publication: Russia (Federation) NLM ID: 9432021 Publication Model: Print Cited Medium: Print ISSN: 0869-2084 (Print) Linking ISSN: 08692084 NLM ISO Abbreviation: Klin Lab Diagn Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : "Meditsina", 1992- |
| مواضيع طبية MeSH: | Precursor Cell Lymphoblastic Leukemia-Lymphoma*/blood , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/diagnosis , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/pathology, Antineoplastic Combined Chemotherapy Protocols/*administration & dosage , Bone Marrow/*pathology , Histone-Lysine N-Methyltransferase/*genetics , Myeloid-Lymphoid Leukemia Protein/*genetics, Female ; Humans ; Infant ; Male ; Neoplasm, Residual ; Prognosis |
| مستخلص: | The occurrence of minimal residual disease is an important prognostic factor under acute lymphoblastic leucosis in children and adults. In overwhelming majority of research studies bone marrow is used to detect minimal residual disease. The comparative characteristic of detection of minimal residual disease in peripheral blood and bone marrow was carried out. The prognostic role of occurrence of minimal residual disease in peripheral blood and bone marrow under therapy according protocol MLL-Baby was evaluated. The analysis embraced 142 pair samples from 53 patients with acute lymphoblastic leucosis and various displacements of gene MLL younger than 365 days. The minimal residual disease was detected by force of identification of chimeric transcripts using polymerase chain reaction in real-time mode in 7 sequential points of observation established by protocol of therapy. The comparability of results of qualitative detection of minimal residual disease in bone marrow and peripheral blood amounted to 84.5%. At that, in all 22 (15.5%) discordant samples minimal residual disease was detected only in bone marrow. Despite of high level of comparability of results of detection of minimal residual disease in peripheral blood and bone marrow the occurrence of minimal residual disease in peripheral blood at various stages of therapy demonstrated no independent prognostic significance. The established differences had no relationship with sensitivity of method determined by value of absolute expression of gene ABL. Most likely, these differences reflected real distribution of tumor cells. The results of study demonstrated that application of peripheral blood instead of bone marrow for monitoring of minimal residual disease under acute lymphoblastic leucosis in children of first year of life is inappropriate. At the same time, retention of minimal residual disease in TH4 in bone marrow was an independent and prognostic unfavorable factor under therapy of acute lymphoblastic leucosis of children of first year of life according protocol MLL-Baby (OO=7.326, confidence interval 2.378-22.565). |
| المشرفين على المادة: | 0 (KMT2A protein, human) 149025-06-9 (Myeloid-Lymphoid Leukemia Protein) EC 2.1.1.43 (Histone-Lysine N-Methyltransferase) |
| تواريخ الأحداث: | Date Created: 20150721 Date Completed: 20150812 Latest Revision: 20190816 |
| رمز التحديث: | 20221213 |
| PMID: | 26189286 |
| قاعدة البيانات: | MEDLINE |
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