التفاصيل البيبلوغرافية
| العنوان: |
[THE NEW APPROACH TO EVALUATION OF ENDOTHELIUM DYSFUNCTION: DETECTION OF NUMBER OF CIRCULATING ENDOTHELIUM CELLS USING FLOW CYTOMETRY TECHNIQUE]. |
| المؤلفون: |
Feoktistova VS, Vavilkova TV, Sirotkina OV, Boldueva SA, Gaikovaia LB, Leonova IA, Laskovets AB, Ermakov AI |
| المصدر: |
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2015 Apr; Vol. 60 (4), pp. 23-6, 39. |
| نوع المنشور: |
Evaluation Study; Journal Article |
| اللغة: |
Russian |
| بيانات الدورية: |
Publisher: Meditsina Country of Publication: Russia (Federation) NLM ID: 9432021 Publication Model: Print Cited Medium: Print ISSN: 0869-2084 (Print) Linking ISSN: 08692084 NLM ISO Abbreviation: Klin Lab Diagn Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Moskva : "Meditsina", 1992- |
| مواضيع طبية MeSH: |
Angina Pectoris*/blood , Angina Pectoris*/pathology , Endothelial Cells*/metabolism , Endothelial Cells*/pathology , Endothelium, Vascular*/metabolism , Endothelium, Vascular*/pathology , Myocardial Ischemia*/blood , Myocardial Ischemia*/pathology, Flow Cytometry/*methods, Adult ; Aged ; Female ; Humans ; Middle Aged |
| مستخلص: |
The endothelium dysfunction takes leading place in pathogenesis of development of cardiovascular diseases. The circulating endothelium cells of peripheral blood can act as a direct cell marker of damage and remodeling of endothelium. The study was carried out to develop a new approach to diagnose of endothelium dysfunction by force of determination of number of circulating endothelium cells using flow cytometry technique and to apply determination of circulating endothelium cells for evaluation of risk of development of ischemic heart disease in women of young and middle age. The study embraced 62 female patients with angiography confirmed ischemic heart disease, exertional angina pectoris at the level of functional class I-II (mean age 51 ± 6 years) and 49 women without anamnesis of ischemic heart disease (mean age 52 ± 9 years). The occurrence of more than three circulating endothelium cells by 3 x 105 leukocytes in peripheral blood increases relative risk of development of ischemic heart disease up to 4 times in women of young and middle age and risk of development of acute myocardial infarction up to 8 times in women with ischemic heart disease. The study demonstrated possibility to apply flow cytometry technique to quantitatively specify circulating endothelium cells in peripheral blood and forecast risk of development of ischemic heart disease in women of young and middle age depending on level of circulating endothelium cells. |
| تواريخ الأحداث: |
Date Created: 20150721 Date Completed: 20150812 Latest Revision: 20191210 |
| رمز التحديث: |
20231215 |
| PMID: |
26189287 |
| قاعدة البيانات: |
MEDLINE |
